AM32792SU-N Laminin P1 Fragment antibody

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1 ml / €550.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rat anti Human, Mouse, Rat Laminin MEC5

AM32792SU-N

Product Description for Laminin

Rat anti Human, Mouse, Rat Laminin MEC5.
Properties: P1 Fragment
Presentation: Supernatant
Product is tested for Frozen Sections.

Properties for Laminin

Product Category Primary Antibodies
Quantity 1 ml
Presentation Supernatant
Reactivity Hu, Ms, Rt
Applications C
Clonality Monoclonal
Clone MEC5
Host Rat
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Property P1 Fragment
Application MEC5 monoclonal antibodies are suitable for Immunohistochemical detection of Laminin in extracellular matrix or basement membranes in freshly frozen tissue sections of Rat, Mouse, or Humans. It is recommended to pretreat the sections with pepsin.
Background Laminin, the most abundant structural and biologically active component in basement membranes, is a complex extracellular glycoprotein with an approximate molecular weight of 900 kDa. It plays an important role in many aspects of the cell biology. Laminin is composed of one A chain (400 kDa) one B1 chain (215 kDa) and one B2 chain (205 kDa) all held together by disulfide bonds. The molecule has a cross like form with globular units near the ends of each chain, the sites where it is bound to Collagen IV, heparan sulfate, proteoglycan as well as to the surface of epithelial cells. Laminins from various species have common antigenic determinants. Laminin is only found in significant quantities in basement membranes, the thin extracellular matrices that surround epithelial tissue, nerve, fat cells and smooth, striated and cardiac muscle. It has been found to modulate cell differentiation, cell shaping and also cell movement because it appears to be an important cell substrate adhesion protein. Variations in the expression of this protein have been observed in embryogenesis, organogenesis, post traumatic healing and cancer. The greatest interest in laminin has been provoked by the discovery of its ability to promote neurite regeneration.
General Readings
  1. Aten J, Veninga A, Coers W, Sonnenberg A, Timpl R, Claessen N, et al. Autoantibodies to the laminin P1 fragment in HgCl2-induced membranous glomerulopathy. Am J Pathol. 1995 Jun;146(6):1467-80. PubMed PMID: 7778685. (Free PMC Article available)
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Preservatives:
0.05% Sodium Azide
State:
Liquid Hybridoma Culture Supernatant
Supernatant
Species Reactivity
Species reactivity (tested):
Human, Mouse, Rat.
Specificity
Specificity:
This Rat monoclonal antibody is directed against the P1 fragment of Laminin. They are species-independent as it has been shown that they bind to Laminin of Rat, Mouse and Human (Aten et al. 1995).
MEC5 is an auto-antibody derived from DZB rats that had developed membranous glomerulopathy upon exposure to Mercuric Chloride (Aten et al. 1995).

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