GTX22738 LAP2 [RL29] antibody

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0.2 ml / €380.00

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Hamster anti Rat LAP2 [RL29] RL29


Product Description for LAP2 [RL29]

Hamster anti Rat LAP2 [RL29] RL29.
Presentation: Ig Fraction
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for LAP2 [RL29]

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Ig Fraction
Reactivity Rt
Applications ICC/IF, IP, WB
Clonality Monoclonal
Clone RL29
Host Hamster
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Application IF, IP, WB
Background In eukaryotic cells, the nuclear envelope consists of inner and outer membranes, which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large, supramolecular assemblies called nuclear pore complexes through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane appears to occur through their association with 4 related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B & 1C share a high degree of sequence homology while LAP 2 is distinct from the others. LAP 1A & B bind lamins A, C and B1, while LAP 2 binds lamin B1 only. In addition to lamin binding, LAP 2 has been shown to bind to chromosomes. Phosphorylation of LAP 2 during mitosis inhibits binding to both lamins and chromosomes suggesting that LAP 2 plays an important role in nuclear envelope re-assembly.
Storage Keep as concentrated solution. Store at 4
IgG fraction
Buffer System:
PBS with 0.05% sodium azide
IgG fraction
Ig Fraction
Cross-reacts with Rat. Not yet tested in other species.

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