discontinued

NSB224 LAT antibody

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0.1 ml / €390.00

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Rabbit anti Human LAT

Product Description for LAT

Rabbit anti Human LAT.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for LAT

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic phospho peptide (Human) derived from a region of LAT that contains tyrosine 132.
Add. information Research Areas: Immunology
Application Western Blot, WB: Detects a band of approximately 38 kDa Optimal dilutions/concentrations should be determined by the end user., Western Blot 0.1 - 1.0 ug/ml
Concentration 0.35 mg/ml
General Readings General / background references:Sommers CL et al. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296:2040-3 (2002). PubMed PMID: 12065840
Perez-Villar JJ et al. Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav. Biochemistry 4132-40 (2002). PubMed PMID: 12186560
Lin J & Weiss A Identification of the minimal tyrosine residues required for linker for activation of T cell function. J Biol Chem 276:29588-95 (2001). PubMed PMID: 11395491
Paz PE et al. Mapping the Zap-70 phosphorylation sites on LAT (linker for activation of T cells) required for recruitment and activation of signalling proteins in T cells. Biochem J 356:461-71 (2001). PubMed PMID: 11368773
Zhang W et al. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem 275:23355-61 (2000). PubMed PMID: 10811803
Storage Store at -80C. Avoid freeze-thaw cycles.
Format
Purification:
Immunogen affinity purified
Buffer System:
Sodium Azide
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
LAT [Tyr132]
Species:
Human

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