NB120-3357 Lewis B antibody

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Mouse anti Lewis B T218


Product Description for Lewis B

Mouse anti Lewis B T218.
Product is tested for Paraffin Sections.

Properties for Lewis B

Product Category Primary Antibodies
Quantity 0.5 ml
Applications P
Clonality Monoclonal
Clone T218
Host Mouse
Isotype IgM
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

SK-CO-10 colon cancer cell line (Human).
Background Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens. Increased expression of Lewis B has been reported in gastric and pancreatic tumors, as well as in colorectal cancer.
General Readings General / background references:Lloyd KO Philip Levine award lecture. Blood group antigens as markers for normal differentiation and malignant change in human tissues. Am J Clin Pathol 87:129-39 (1987). PubMed PMID: 3541575
Sakamoto J et al. Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines. Cancer Res 46:1553-61 (1986). PubMed PMID: 3510728
Cordon-Cardo C et al. Immunohistologic expression of blood-group antigens in normal human gastrointestinal tract and colonic carcinoma. Int J Cancer 37:667-76 (1986). PubMed PMID: 3516890
Cordon-Cardo C et al. Immunoanatomic distribution of blood group antigens in the human urinary tract. Influence of secretor status. Lab Invest 55:444-54 (1986). PubMed PMID: 2429066
IgM purified
Buffer System:
Preservative: 0.1% Sodium AzideConstituents: 1% BSA, PBS
IgM purified
Cross-reacts with Human.Not yet tested in other species.

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