SM3119D6 Linker of Activated T cells (LAT) antibody

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Mouse anti Human Linker of Activated T cells (LAT) LAT-01


Product Description for Linker of Activated T cells (LAT)

Mouse anti Human Linker of Activated T cells (LAT) LAT-01.
Presentation: DY647
Product is tested for Flow Cytometry.

Properties for Linker of Activated T cells (LAT)

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation DY647
Reactivity Hu
Applications F
Clonality Monoclonal
Clone LAT-01
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT
Application Flow cytometry: 1:1000.
Background LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FceRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Concentration 1.0 mg/ml
General Readings
  1. Horejsí V, Zhang W, Schraven B. Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol. 2004 Aug;4(8):603-16. PubMed PMID: 15286727.
  2. Simeoni L, Smida M, Posevitz V, Schraven B, Lindquist JA. Right time, right place: the organization of membrane proximal signaling. Semin Immunol. 2005 Feb;17(1):35-49. PubMed PMID: 15582487.
  3. Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, et al. LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol. 2007 Jun;27(12):4406-15. Epub 2007 Apr 9. PubMed PMID: 17420272. (Free PMC Article available, 6 images available)
  4. Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rüdiger T, Angelisova P, et al. Transmembrane adaptor molecules: a new category of lymphoid-cell markers. Blood. 2006 Jan 1;107(1):213-21. Epub 2005 Sep 13. PubMed PMID: 16160011.
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Conjugated with Dyomics 647 under optimum conditions. The conjugate is purified by size-exclusion chromatography
Buffer System:
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Liquid purified Ig fraction
This antibody reacts with Linker for activation of T cells (LAT), a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
Human. Does not work in mouse.

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