discontinued

SM3119D6 Linker of Activated T cells (LAT) antibody

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0.1 mg / €260.00

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Mouse anti Human Linker of Activated T cells (LAT) LAT-01

SM3119D6

Product Description for Linker of Activated T cells (LAT)

Mouse anti Human Linker of Activated T cells (LAT) LAT-01.
Presentation: DY647
Product is tested for Flow Cytometry.

Properties for Linker of Activated T cells (LAT)

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation DY647
Reactivity Hu
Applications F
Clonality Monoclonal
Clone LAT-01
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Bacterially produced recombinant polypeptide corresponding to the entire cytoplasmic domain of human LAT
Isotype control AM03095D6-N
Application Flow cytometry: 1:1000.
Background LAT (Linker for Activation of T cells) is a 36-38 kDa double-palmitoylated transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets. After immunoreceptor triggering, LAT becomes multiply tyrosine-phosphorylated by Syk-, Src-, or Tec-family kinases, providing docking sites for downstream signaling molecules. LAT is essential for TCR-dependent T cell- and FceRI-dependent mast cell activation, as well as for maturation of early thymocytes. It is also involved in NK cell signaling and platelet activation.
Concentration 1.0 mg/ml
General Readings
  1. Horejsí V, Zhang W, Schraven B. Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol. 2004 Aug;4(8):603-16. PubMed PMID: 15286727.
  2. Simeoni L, Smida M, Posevitz V, Schraven B, Lindquist JA. Right time, right place: the organization of membrane proximal signaling. Semin Immunol. 2005 Feb;17(1):35-49. PubMed PMID: 15582487.
  3. Yamasaki S, Ishikawa E, Sakuma M, Kanagawa O, Cheng AM, Malissen B, et al. LAT and NTAL mediate immunoglobulin E-induced sustained extracellular signal-regulated kinase activation critical for mast cell survival. Mol Cell Biol. 2007 Jun;27(12):4406-15. Epub 2007 Apr 9. PubMed PMID: 17420272. (Free PMC Article available, 6 images available)
  4. Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rüdiger T, Angelisova P, et al. Transmembrane adaptor molecules: a new category of lymphoid-cell markers. Blood. 2006 Jan 1;107(1):213-21. Epub 2005 Sep 13. PubMed PMID: 16160011.
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
Conjugated with Dyomics 647 under optimum conditions. The conjugate is purified by size-exclusion chromatography
DY647
Buffer System:
Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State:
Liquid purified Ig fraction
Specificity
Specificity:
This antibody reacts with Linker for activation of T cells (LAT), a 36-38 kDa transmembrane adaptor protein expressed by T cells, pre-B cells, NK cells, mast cells and platelets.
Species:
Human. Does not work in mouse.

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