NB110-41568G LOX propeptide antibody

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0.1 ml / €390.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Monkey, Mouse, Porcine, Rat LOX propeptide


Product Description for LOX propeptide

Rabbit anti Human, Monkey, Mouse, Porcine, Rat LOX propeptide.
Presentation: DyLight488
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for LOX propeptide

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms anti-Lysyl oxidase propeptide antibody
Presentation DyLight488
Reactivity Hu, Mky, Ms, Por, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

A synthetic peptide made to an internal region of the mouse protein (residues 78-115).
Application immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, This antibody is useful for Western Blot where a band is seen at ~18 kDa. The strong band at 50 kDa and smear of bands that run between 46 kDa and 50 kDa are glycosylated and non-glycosylated forms of pro-lysyl oxidase. Bands between 28-36 kDa are glycosylated propeptide. The variation in MW depends on the extent of glycosylation. This antibody is also useful for immunohistochemistry on paraffin tissues., immunohistochemistry 0.5-1.0 ug/ml, Western Blot , Immunohistochemistry-Paraffin 1:100-1:250
Background Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. LOX is synthesized as a 50 kDa precursor, secreted into the extracellular matrix and subsequently proteolytically processed to a 30 kDa active enzyme and an 18 kDa propeptide. LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.
Concentration 1 mg/ml
Storage Store at 4C. Do not freeze.
DyLight 488
Affinity purified
Buffer System:
No Preservative
Affinity purified
This recognizes the pro-enzyme (50 kDa) and pro-peptide. The pro-peptide runs at ~18-20 kDa when not glycosylated and ~35 kDa on SDS-PAGE when N-glycosylated.
Mouse, Rat

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