NB110-41568H LOX propeptide antibody

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0.1 ml / €390.00
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Rabbit anti Human, Monkey, Mouse, Porcine, Rat LOX propeptide

NB110-41568H

Product Description for LOX propeptide

Rabbit anti Human, Monkey, Mouse, Porcine, Rat LOX propeptide.
Presentation: HRP
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for LOX propeptide

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms anti-Lysyl oxidase propeptide antibody
Presentation HRP
Reactivity Hu, Mky, Ms, Por, Rt
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
A synthetic peptide made to an internal region of the mouse protein (residues 78-115).
Application immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, This antibody is useful for Western Blot where a band is seen at ~18 kDa. The strong band at 50 kDa and smear of bands that run between 46 kDa and 50 kDa are glycosylated and non-glycosylated forms of pro-lysyl oxidase. Bands between 28-36 kDa are glycosylated propeptide. The variation in MW depends on the extent of glycosylation. This antibody is also useful for immunohistochemistry on paraffin tissues., immunohistochemistry 0.5-1.0 ug/ml, Western Blot , Immunohistochemistry-Paraffin 1:100-1:250
Background Lysyl oxidase (LOX) is an extracellular enzyme that is critical for the normal biosynthesis of collagens and elastin. LOX is synthesized as a 50 kDa precursor, secreted into the extracellular matrix and subsequently proteolytically processed to a 30 kDa active enzyme and an 18 kDa propeptide. LOX also reverts ras-mediated transformation and its expression is down-regulated in human cancers. Most recently, the lysyl oxidase pro-peptide (LOPP) has been associated with tumor suppression, as it inhibits ras-dependent cellular transformation.
Concentration 1 mg/ml
Storage Store at 4C. Do not freeze.
Format
Label:
HRP
Purification:
Affinity purified
Buffer System:
No Preservative
Purity:
Affinity purified
Specificity
Specificity:
This recognizes the pro-enzyme (50 kDa) and pro-peptide. The pro-peptide runs at ~18-20 kDa when not glycosylated and ~35 kDa on SDS-PAGE when N-glycosylated.
Species:
Mouse, Rat

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