TA322731 LRP2 antibody

Anti-LRP2 Rabbit Polyclonal Antibody

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Search for all "LRP2"

0.1 ml / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse, Rat LRP2

Product Description for LRP2

Rabbit anti Human, Mouse, Rat LRP2.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections.

Properties for LRP2

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2, Megalin
Presentation Purified
Reactivity Hu, Ms, Rt
Applications E, P
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P98164
Immunogen:
Synthetic peptide corresponding to a region derived from 4640-4054 amino acids of Human low density lipoprotein receptor-related protein 2.
GeneID:
4036
Application ELISA: 1:1000-10000
IHC: 1:50-200
Background The protein encoded by this gene; low density lipoprotein-related protein 2 (LRP2) or megalin; is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-termil extracellular domain; a single transmembrane domain; and a short carboxy-termil cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin; apolipoproteins B and E; and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands; including lipoproteins; sterols; vitamin-binding proteins; and hormones. This protein also has a role in cell-sigling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kise scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Doni-Barrow syndrome (DBS) and facio-oculoacoustico-rel syndrome (FOAR).
Format
Purification:
Antigen affinity purification
Buffer System:
PBS pH7.3, 0.05% NaN3, 50% glycerol.
State:
Purified

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