TA352255 LRP2 antibody

Mouse Monoclonal anti-LRP2 Antibody

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Mouse anti Human, Mouse, Rat LRP2 CD7D5

Product Description for LRP2

Mouse anti Human, Mouse, Rat LRP2 CD7D5.
Presentation: Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for LRP2

Product Category Primary Antibodies
Target Category
Quantity 100 µl
Synonyms Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2, Megalin
Presentation Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, P
Clonality Monoclonal
Clone CD7D5
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
This monoclonal antibody was raised against purified human LRP2 protein.
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Application IHC
Background Megalin or low density lipoprotein-related protein 2 (LRP2), is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithelial tissues such as the kidney. LRP2 mediates uptake of Apo-J which is a binding protein for Amyloid beta. Megalin has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. Megalin is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. It also has a role in cell-signaling; extracellular ligands include parathyroid hormones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in the LRP2 gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
The antibody was purified by affinity chromatography.
Buffer System:
Phosphate-buffered solution.

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