discontinued

AP13118PU-N LRP4 (C-term) antibody

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0.1 mg / €335.00

Quick Overview

Rabbit anti Human LRP4

Product Description for LRP4

Rabbit anti Human LRP4.
Properties: (C-term)
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for LRP4

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms Low density lipoprotein receptor-related protein 4
Presentation Purified
Reactivity Hu
Applications P
Clonality Polyclonal
Host Rabbit
Isotype Ig
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q5KTZ5
Immunogen:
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human LRP4.
GeneID:
4038
Property C-term
Application ELISA: 1/1,000.
Immunohistochemistry: 1/50 - 1/100.
Background Low density lipoprotein (LDL) receptor-related protein (LRP), a member of the LDL receptor family, binds multiple classes of ligands and has been implicated in a broad range of normal and disease processes involving lipid metabolism, protease clearance, and cell migration (1). Structurally, members of the LDLR family share homology within their extracellular domains, which are highlighted by the presence of clusters of ligand-binding repeats. LRP is a large endocytic receptor that participates in several biological pathways and plays prominent roles in lipoprotein metabolism and in the catabolism of proteinases involved in coagulation and fibrinolysis. LRP also mediates the cellular entry of certain viruses and toxins and facilitates the activation of various lysosomal enzymes (2). All LRPs are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are varied and include the transduction of extracellular signals and the modulation of intracellular signal propagation, as well as cargo transport, the function most commonly attributed to this gene family (3).
Caution This product is for research use only. Not for use in diagnostic or therapeutic procedures.
Concentration 0.25 mg/ml
General Readings
  1. Grimsley PG, et al. Trends Cardiovasc Med. 1998:363
  2. Strickland DK & Ranganathan S. J Thromb Haemost. 2003:1663
  3. May P and Herz J. Traffic. 2003:291
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Buffer System:
PBS with 0.09% (W/V) sodium azide
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody reacts to LRP4.
Species:
Human.
Gene ID 4038

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