AM00196PU-N LRP5 + LRP6 antibody

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Mouse anti Human, Mouse LRP5 + LRP6 1A12


Product Description for LRP5 + LRP6

Mouse anti Human, Mouse LRP5 + LRP6 1A12.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for LRP5 + LRP6

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms LRP5, LRP6, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6
Presentation Purified
Reactivity Hu, Ms
Applications WB
Clonality Monoclonal
Clone 1A12
Host Mouse
Isotype IgG2b
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Synthetic peptide (DTGTDRIEVTR) derived from Human LRP-6. These residues are completely conserved between Human and Mouse and between LRP-5 and LRP-6.
Isotype control AM03110PU-N, SM12P
Application Western blot: 1-2 μg/ml.
Background LDL-related proteins, LRP-5 and LRP-6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP-5 to Axin, leading Axin degradation and β-catenin stabilization.
Concentration 1.0 mg/ml
General Readings
  1. Li, L., et al. (2002) J. Biol. Chem. 277:5977-5981.
Storage Store the antibody undiluted at -20°C or for long term storage (in aliquots) at -70°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography.
Buffer System:
10 mM Tris-glycine (pH 7.0) containing 0.15M NaCl, 25% Glycerol, 0.5% BSA, and 0.01% Sodium Azide
Liquid purified IgG fraction.
Detects full length and a proteolytic fragment of LRP-6.
Human and Mouse.

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