AP00345PU-N LRP5 + LRP6 antibody

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0.1 mg / €330.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human, Mouse LRP5 + LRP6

Product Description for LRP5 + LRP6

Rabbit anti Human, Mouse LRP5 + LRP6.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for LRP5 + LRP6

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms LRP5, LRP6, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Synthetic peptide surrounding amino acid 437 of Human LRP.
Control peptide AP00345CP-N
Add. information Blocking Peptide (AP00345CP-N) is also available separately.
Application Western blot: 0.5-4.0 µg/ml.
Jurkat cell lysate can be used as a Positive Control.
Background LDL-related proteins LRP-5 and LRP-6. are members of the LDL receptor superfamily, which were found to be involved in the canonical Want signaling pathway. Mammalian LRP-6 was shown to bind to Wnt-1 and enhance Induced-induced developmental processes in Xenopus embryos. Mice lacking LRP-6 exhibited developmental defects that are similar to those caused by deficiencies in various Want proteins. Recent work also shows that Want proteins induce the binding of LRP-5 to Axin, leading Axin degradation and beta-catenin stabilization.
Concentration 0.5 mg/ml
Product Citations
Purchased from Acris:
  1. Casagolda D, Del Valle-Pérez B, Valls G, Lugilde E, Vinyoles M, Casado-Vela J, et al. A p120-catenin-CK1epsilon complex regulates Wnt signaling. J Cell Sci. 2010 Aug 1;123(Pt 15):2621-31. doi: 10.1242/jcs.067512. PubMed PMID: 20940130.
  2. Del Valle-Pérez B, Arqués O, Vinyoles M, de Herreros AG, Duñach M. Coordinated action of CK1 isoforms in canonical Wnt signaling. Mol Cell Biol. 2011 Jul;31(14):2877-88. doi: 10.1128/MCB.01466-10. Epub 2011 May 23. PubMed PMID: 21606194. (Free PMC Article available, 9 images available)
Storage Upon receipt, store the antibody undiluted at -20°C or at -70°C (in aliquots) for long term storage.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography
Buffer System:
PBS containing 30% Glycerol, 0.5% BSA and 0.01% Thimerosal as preservative
Liquid purified Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human and Mouse.
The antibody recognizes the ~170 kDa full length LRP-5/6.
A cleavage fragment (~120 kDa) can also be detected.

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