NB100-649 LRP5 + LRP6 antibody

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50 µg / €360.00
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Mouse anti Human, Mouse LRP5 + LRP6 1A12

NB100-649

Product Description for LRP5 + LRP6

Mouse anti Human, Mouse LRP5 + LRP6 1A12.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for LRP5 + LRP6

Product Category Primary Antibodies
Quantity 50 µg
Synonyms LRP5, LRP6, LRP7, Low-density lipoprotein receptor-related protein 5, Low-density lipoprotein receptor-related protein 6
Presentation Purified
Reactivity Hu, Ms
Applications WB
Clonality Monoclonal
Clone 1A12
Host Mouse
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic peptide: DTGTDRIEVTR (Human). These residues are completely conserved between human and mouse; and between LRP 5 and LRP 6.
Isotype control AM03110PU-N, SM12P
Add. information Research Areas: Neuroscience
Application Western Blot, Western Blot , Western Blot 1-2 ug/ml
Background LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading to Axin degradation and beta catenin stabilization.
Concentration 1 mg/ml
General Readings Li L et al. Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled. J Biol Chem 277:5977-81 (2002). PUBMED:11742004
Storage Store at -20C. Avoid freeze-thaw cycles.
Format
Purification:
IgG purified
Buffer System:
Sodium Azide
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
This recognizes both full length and proteolytic fragments of LRP 6 and LRP 5.
Species:
Human, Mouse

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