AP07703PU-N LRP6 (Internal) antibody

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50 µg / €425.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Goat anti Canine, Equine, Hamster, Human, Monkey, Porcine, Rabbit, Rat LRP6

Product Description for LRP6

Goat anti Canine, Equine, Hamster, Human, Monkey, Porcine, Rabbit, Rat LRP6.
Properties: (Internal)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections.

Properties for LRP6

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms LRP-6, Low-density lipoprotein receptor-related protein 6
Presentation Aff - Purified
Reactivity Can, Elephant, Eq, Hst, Hu, Mky, Por, Rb, Rt
Applications E, P
Clonality Polyclonal
Host Goat
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O75581
Immunogen:
Synthetic peptide from an internal region of human LRP6 (NP_002327.2)
AA Sequence:
CMTSVATAKGYTSDL
GeneID:
4040
Property Internal
Application ELISA: 1/64000.
Immunohistochemistry on Paraffin Sections: 5 µg/ml.
Background Essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. Specific high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
Defects in LRP6 are the cause of autosomal dominant coronary artery disease type 2 (ADCAD2).
Subcellular location: Membrane and Single-pass type I membrane protein.
Concentration 0.5 mg/ml
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Immunoaffinity Chromatography
Buffer System:
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
State:
Liquid purified IgG fraction
Aff - Purified
Species Reactivity
Species reactivity (expected):
Gorilla, Gibbon, Monkey, Marmoset, Rat, Hamster, Panda, Dog, Horse, Rabbit, Pig, Mouse, Elephant, Bovine, Bat.
Species reactivity (tested):
Human.
Specificity
Specificity:
This antibody recognizes an epitope corresponding to amino acis 1546-1560 of Human LRP6.
Gene ID 4040

Accessory Products

Proteins and/or Positive Controls

Positive controls for LRP6 (2 products)

Catalog No. Species Pres. Purity   Source  

LRP6 Lysate

Western Blot: LRP6 Lysate [NBL1-12672] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for LRP6
  Novus Biologicals Inc.

LRP6 overexpression lysate

LRP6 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
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