TA306094 LRRC1 antibody

Rabbit Polyclonal Lano Antibody

See related secondary antibodies

Search for all "LRRC1"

0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human LRRC1

TA306094

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  • TA306094
  • TA306094

Product Description for LRRC1

Rabbit anti Human LRRC1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for LRRC1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms LANO, LANO adapter protein, LAP and no PDZ protein, LRRC1, Leucine-rich repeat-containing protein 1
Presentation Aff - Purified
Reactivity Hu
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9BTT6
Immunogen:
Lano antibody was raised against a peptide corresponding to 15 amino acids near the carboxy terminus of human Lano.
GeneID:
55227
Add. information Blocking peptide available: AP30489CP-N
Application ELISA.
Western blot: 1 -2 μg/ml.
Immunohistochemistry on paraffin sections.
Background Lano is a member of the LAP (leucine-rich repeats and PDZ) family of proteins that also includes Densin-180, Erbin, and hScribble (1). The LAP proteins generally contain multiple leucine-rich repeat (LRR) domains which serve to target them to the basolateral membrane of epithelial cells (2). Lano is unique in that it alone does not possess one or more PDZ (PSD95/DLG/ZO-1) domains as do the other members of the LAP family. However, it can bind to the PDZ domain of Erbin in addition to those of membrane-associated and guanylate kinase (MAGUK) proteins which regulate adhesion and plasticity at cell junctions (1,3). It has been suggested that it is through these interaction that these LAP proteins participate in the maintenance of proper embryonic development and integrity of epithelial tissues (4,5).
General Readings
  1. Saito H, Santoni MJ, Arsanto JP, Jaulin-Bastard F, Le Bivic A, Marchetto S, et al. Lano, a novel LAP protein directly connected to MAGUK proteins in epithelial cells. J Biol Chem. 2001 Aug 24;276(34):32051-5. Epub 2001 Jul 5. PubMed PMID: 11440998.
  2. Legouis R, Jaulin-Bastard F, Schott S, Navarro C, Borg JP, Labouesse M. Basolateral targeting by leucine-rich repeat domains in epithelial cells. EMBO Rep. 2003 Nov;4(11):1096-102. Epub 2003 Oct 24. PubMed PMID: 14578922. (Free PMC Article available, 5 images available)
  3. Funke L, Dakoji S, Bredt DS. Membrane-associated guanylate kinases regulate adhesion and plasticity at cell junctions. Annu Rev Biochem. 2005;74:219-45. PubMed PMID: 15952887.
  4. Bilder D, Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature. 2000 Feb 10;403(6770):676-80. PubMed PMID: 10688207.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Peptide affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody detects LRRC1.

Accessory Products

Proteins and/or Positive Controls

Positive controls for LRRC1 (2 products)

Catalog No. Species Pres. Purity   Source  

Lano Lysate

Western Blot: Lano Lysate [NBL1-12674] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for LRRC1
  Novus Biologicals Inc.

LRRC1 overexpression lysate

LRRC1 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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