TA319771 LRRFIP1 (C-term) antibody

Rabbit Polyclonal LRRFIP1 Antibody

See related secondary antibodies

Search for all "LRRFIP1"

0.1 mg / €371.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Human LRRFIP1

TA319771

More Views

  • TA319771
  • TA319771

Product Description for LRRFIP1

Rabbit anti Human LRRFIP1.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for LRRFIP1

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms GC-binding factor 2, GCF2, LRR FLII-interacting protein 1, Leucine-rich repeat flightless-interacting protein 1, TAR RNA-interacting protein, TRIP
Presentation Aff - Purified
Reactivity Hu
Applications E, WB
Clonality Polyclonal
Host Rabbit
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q32MZ4
Immunogen:
19 amino acid peptide near the carboxy terminus of human LRRFIP1
GeneID:
9208
Property C-term
Application ELISA.
Western blot: 1-2 µg/ml.
Positive control: Human Colon Tissue Lysate.
Background LRRFIP1, also known as GC-binding factor 2 (GCF2), is a 738 amino acid transcriptional repressor that mainly plays a cytoskeletal role. It is primarily localized in the cytoplasm and preferentially binds to GC-rich dsDNA, but will also bind directly to dsRNA as well. The RNA binding domain encompasses a lysine-rich motif. LRRFIP1 interacts with the mammalian Flightless I (Fli-I) and is a key component in the cytoskeletal regulation of platelet function. LRRFIP1 and the related protein LRRFIP2 may modulate canonical WNT signaling and mediate the IRF3-induced production of type I interferon via a B-catenin-dependent pathway.
General Readings
  1. Rikiyama T, Curtis J, Oikawa M, Zimonjic DB, Popescu N, Murphy BA, et al. GCF2: expression and molecular analysis of repression. Biochim Biophys Acta. 2003 Oct 1;1629(1-3):15-25. PubMed PMID: 14522076.
  2. Suriano AR, Sanford AN, Kim N, et al. GCF2/LRRFIP1 represses tumor necrosis factor ? expression. Mol. Cell. Biol. 2005; 25:9073-81.
  3. Wilson SA, Brown EC, Kingsman AJ, Kingsman SM. TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I. Nucleic Acids Res. 1998 Aug 1;26(15):3460-7. PubMed PMID: 9671805. (Free PMC Article available)
  4. Goodall AH, Burns P, Salles I, Macaulay IC, Jones CI, Ardissino D, et al. Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood. 2010 Nov 25;116(22):4646-56. doi: 10.1182/blood-2010-04-280925. Epub 2010 Sep 10. PubMed PMID: 20833976. (Free PMC Article available, 6 images available)
Storage Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography purified via peptide column
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human
Specificity
Specificity:
This antibody detects LRRFIP1 at C-term.
LRRFIP1 antibody is predicted to not cross-react with other LRRFIP family members. Three isoforms of LRRFIP1 are known to exist; this antibody will only recognize the two longer isoforms.

Accessory Products

Proteins and/or Positive Controls

Proteins for LRRFIP1 (5 products)

Catalog No. Species Pres. Purity   Source  

LRRFIP1 (transcript variant 4)

LRRFIP1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

LRRFIP1

LRRFIP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

LRRFIP1

LRRFIP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

LRRFIP1

LRRFIP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

LRRFIP1

LRRFIP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for LRRFIP1 (3 products)

Catalog No. Species Pres. Purity   Source  

LRRFIP1 293T Cell Transient Overexpression Lysate(Denatured)

LRRFIP1 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.

LRRFIP1 Lysate

Western Blot: LRRFIP1 Lysate [NBL1-12709] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for LRRFIP1
  Novus Biologicals Inc.

LRRFIP1 overexpression lysate

LRRFIP1 overexpression lysate
0.1 mg / €495.00
  OriGene Technologies, Inc.
  • LinkedIn