NB100-77624 Ly-49A antibody

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Rat anti Mouse Ly-49A YE1/48.10.6


Product Description for Ly-49A

Rat anti Mouse Ly-49A YE1/48.10.6.
Presentation: Biotin
Product is tested for Flow Cytometry.

Properties for Ly-49A

Product Category Primary Antibodies
Quantity 0.5 mg
Presentation Biotin
Reactivity Ms
Applications F
Clonality Monoclonal
Clone YE1/48.10.6
Host Rat
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Con A activated splenic T cells
Application flow cytometry / FACS analysis
Background Ly-49A is a 44 kD member of the C-type lectin/Ly-49 family proteins. It is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Ly-49A is present on a subset of NK and NK-T cells. Ly-49A, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. The Ly-49A receptor recognizes H-2Dd and H-2Dk, triggering phosphorylation of the ITIM motif in the cytoplasmic domain and recruitment of SHP-1 and SHP-2. The YE1/48.10.6 antibody reacts with NK cells from all mouse strains tested and reverses the inhibition of NK cytotoxicity.
General Readings
  1. Coles, M.C, et al., 2000. Eur. J. Immunol. 30:236. 2. Takei, F.J., et al., 1997. Immunol. Rev. 155:67. 3. Hanke, T., et al., 1999. Immunity 11:67.
Storage Store at 4C. Do not freeze. Do not freeze.
Immunogen affinity purified
Buffer System:
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Immunogen affinity purified

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