discontinued

NB100-77518 Ly49C/F/H/I antibody

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0.5 mg / €400.00

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Hamster anti Mouse Ly49C/F/H/I 14B11

Product Description for Ly49C/F/H/I

Hamster anti Mouse Ly49C/F/H/I 14B11.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for Ly49C/F/H/I

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms Ly-49C, Ly-49F, Ly-49H, Ly-49I, Ly49C, Ly49F, Ly49H, Ly49I, T cell surface glycoprotein Ly 49C, T cell surface glycoprotein Ly 49F, T cell surface glycoprotein Ly 49H, T cell surface glycoprotein Ly 49I
Presentation FITC
Reactivity Ms
Applications F
Clonality Monoclonal
Clone 14B11
Host Hamster
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q61198
Immunogen:
IL-2-activated killer cells (LAK) from C57BL/6 mic
GeneID:
16634
Application flow cytometry / FACS analysis, flow cytometry / FACS analysis For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. , flow cytometry / FACS analysis
Background The 14B11 antibody reacts with a common epitope of Ly-49C/F/I/H family members also known as Ly-49 inhibitory receptors C, F, and I and activating receptor H. It does not react with other Ly-49 members (i.e., Ly-49A, B, D, and G). Ly-49 is a type-II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains that binds to MHC class I. Ly-49C/F/I/H is expressed on a subset of NK cells, NK-T cells and some CD8+ cells. Ly-49C/F/I, like other members of this family, inhibits NK cell activation through the recognition and interaction of certain MHC class I haplotypes on potential target cells. Ly-49C, Ly-49F, and Ly-49I contain an ITIM motif in their cytoplasmic tails, while Ly-49H lacks ITIM. Ly-49H is encoded by the Cmv1r gene, which promotes resistance to infection by mouse cytomegalovirus (CMV). BALB/c mice are reported to lack the Ly-49H and Ly-49I receptors. The 14B11 antibody, when bound to NK cells, is capable of inducing redirected cell lysis and blocking NK cell effector function.
General Readings
  1. Ryan, J. C., et al., 1997. Immunol. Rev. 155:79. 2. Mason, L. H., et al., 1997. J. Immunol. 159:4187. 3. Lanier, L.L. 1998. Ann. Rev. Immunol. 16:359.
Storage Store at 4C. Do not freeze.
Format
Label:
FITC
Purification:
Immunogen affinity purified
Buffer System:
0.09% Sodium Azide
Purity:
Immunogen affinity purified
Specificity
Specificity:
Ly-49C/F/I/H (14B11)
Species:
Mouse
Gene ID 16634

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