discontinued

NB100-78476 Lyn antibody

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0.1 mg / €350.00

Quick Overview

Mouse anti Human, Mouse, Rat Lyn LYN-01

Product Description for Lyn

Mouse anti Human, Mouse, Rat Lyn LYN-01.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Western blot / Immunoblot.

Properties for Lyn

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications ICC/IF, IP, WB
Clonality Monoclonal
Clone LYN-01
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Partial recombinant Lyn (aa 8-238) expressed in bacteria
Application Immunocytochemistry, immunoprecipitation, Western Blot
Background Lyn is a tyrosine protein kinase and a member of the src subfamily. Two isoforms of Lyn have been reported: Lyn A, 53 kD and Lyn B, 56 kD. Lyn is predominantly expressed in macrophages, B cells, and platelets. Lyn exhibits both stimulatory activity (mast cells) and inhibitory activity (B cells), and has been shown to increase p53 levels and inhibit nuclear export. Recent reports have suggested that Lyn may participate in the induction of apoptosis by genotoxic agents. Lyn has been shown to be activated in late G1 by stem cell factor and is increased in myeloid leukemias. Lyn interacts with the high affinity IgE receptor, actin cytoskeleton, gamma-tubulin, and p53. The LYN-01 monoclonal antibody recognizes the human, mouse, and rat Lyn and has been shown to be useful for Western blotting, immunoprecipitation, and immunocytochemistry.
General Readings
  1. Yamanashi, Y., et al., 1987. Mol. Cell. Biol. 7:237. 2. Rider, L., et al., 1994. Gene 138:219.
Storage Store at 4C. Do not freeze.
Format
Purification:
Immunogen affinity purified
Buffer System:
This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Human, Mouse, Rat.

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