DP3513P LYVE-1 antibody

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50 µg / €280.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Mouse, Rat LYVE-1


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  • DP3513P
  • DP3513P

Product Description for LYVE-1

Rabbit anti Mouse, Rat LYVE-1.
Presentation: Aff - Purified
Product is tested for Immunocytochemistry/Immunofluorescence, Frozen Sections, Enzyme Immunoassay, Western blot / Immunoblot, Flow Cytometry, Paraffin Sections.

Properties for LYVE-1

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms CRSBP-1, CRSBP1, Cell surface retention sequence-binding protein 1, Extracellular link domain-containing protein 1, HAR, Hyaluronic acid receptor, LYVE1, Lymphatic vessel endothelial hyaluronic acid receptor 1, XLKD1
Presentation Aff - Purified
Reactivity Ms, Rt
Applications C, E, F, ICC/IF, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Swiss Prot Num:
Highly pure (> 95%) recombinant Mouse soluble LYVE-1 (Ala24-Gly228) produced in insect cells (Cat.-No DA3524).
The recombinant soluble LYVE-1 consists of amino acid 24 (Ala) to 228 (Gly) and is fused to a C-terminal His-tag (6xHis).
Application ELISA: 1-15 µg/ml.
Western blot: 2-5 µg/ml.
FACS analysis: 3-10 µg/ml. 
Immunohistochemistry on Paraffin and Frozen Sections: 0.25-4 µg/ml.
Background LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.
Product Citations
Purchased from Acris:
  1. Conrad C, Niess H, Huss R, Huber S, von Luettichau I, Nelson PJ, et al. Multipotent mesenchymal stem cells acquire a lymphendothelial phenotype and enhance lymphatic regeneration in vivo. Circulation. 2009 Jan 20;119(2):281-9. doi: 10.1161/CIRCULATIONAHA.108.793208. Epub 2008 Dec 31. PubMed PMID: 19118255.
  2. Heishi T, Hosaka T, Suzuki Y, Miyashita H, Oike Y, Takahashi T, et al. Endogenous angiogenesis inhibitor vasohibin1 exhibits broad-spectrum antilymphangiogenic activity and suppresses lymph node metastasis. Am J Pathol. 2010 Apr;176(4):1950-8. doi: 10.2353/ajpath.2010.090829. Epub 2010 Feb 4. PubMed PMID: 20133819. (Free PMC Article available, 8 images available)
Originator or purchased from resellers:
  1. Nakao S, Zandi S, Faez S, Kohno R, Hafezi-Moghadam A. Discontinuous LYVE-1 expression in corneal limbal lymphatics: dual function as microvalves and immunological hot spots. FASEB J. 2012 Feb;26(2):808-17. doi: 10.1096/fj.11-183897. Epub 2011 Nov 16. PubMed PMID: 22090317. (Free PMC Article available, 7 images available)
General Readings
  1. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, et al. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001 Nov 15;61(22):8079-84. PubMed PMID: 11719431.
  2. Jackson DG. The lymphatics revisited: new perspectives from the hyaluronan receptor LYVE-1. Trends Cardiovasc Med. 2003 Jan;13(1):1-7. PubMed PMID: 12554094.
  3. Sleeman JP, Krishnan J, Kirkin V, Baumann P. Markers for the lymphatic endothelium: in search of the holy grail? Microsc Res Tech. 2001 Oct 15;55(2):61-9. PubMed PMID: 11596151.
  4. Mäkinen T, Veikkola T, Mustjoki S, Karpanen T, Catimel B, Nice EC, et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3. EMBO J. 2001 Sep 3;20(17):4762-73. PubMed PMID: 11532940. (Free PMC Article available, 8 images available)
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month 
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Antigen Affinity Chromatography
Buffer System:
PBS, pH 7.4, without preservatives or stabilizers
Lyophilized purified IgG fraction
Aff - Purified
Restore in distilled sterile Water to a concentration of 0.1-1.0 mg/ml.
Species Reactivity
Species reactivity (tested):
Mouse, Rat.
Cross reactivity of anti-Mouse Lyve-1 with Rat tissue.
The anti-Mouse Lyve-1 polyclonal antibody Cat.-No DP3513P shows a strong cross reaction with Rat Lyve-1 protein.
Gene ID 114332
FocusOn and Reviews

Accessory Products

Proteins and/or Positive Controls

Proteins for LYVE-1 (2 products)

Catalog No. Species Pres. Purity   Source  


LYVE-1 Mouse Purified > 95 % by SDS-PAGE and visualised by silver stain Insect cells
  Acris Antibodies GmbH


LYVE-1 Mouse Purified > 95 % by SDS-PAGE and visualised by silver stain Insect cells
  Acris Antibodies GmbH
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