NB100-75320 M-phase inducer phosphatase 3 antibody

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Chicken anti Human M-phase inducer phosphatase 3


Product Description for M-phase inducer phosphatase 3

Chicken anti Human M-phase inducer phosphatase 3.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for M-phase inducer phosphatase 3

Product Category Primary Antibodies
Quantity 0.05 mg
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

The immunogen for this antibody was a sequence from 351a.a. to 400a.a. from M-phase inducer phosphatase 3(a 400a.a. long protein)
Application Western Blot
Background Cdc25C is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It has been highly conserved during evolution and it plays a key role in the regulation of cell division. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Cdc25C is mainly expressed in G2 phase. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.

Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.
General Readings
  1. Garcia-Alvarez,B., Ibanez,S. and Montoya,G., et al. Crystallization and preliminary X-ray diffraction studies on the human Plk1 Polo-box domain in complex with an unphosphorylated and a phosphorylated target peptide from Cdc25C
  2. Bachmann,M., Kosan,C., Xing,P.X., Montenarh,M., Hoffmann,I. and Moroy,T. The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C
  3. Thomas,C.G., Vezyraki,P.E., Kalfakakou,V.P. and Evangelou,A.M., et al. Vitamin C transiently arrests cancer cell cycle progression in S phase and G2/M boundary by modulating the kinetics of activation and the subcellular localization of Cdc25C phosphatase
  4. Ozen,M. and Ittmann,M., et al. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer
  5. Kino,T., Gragerov,A., Valentin,A., Tsopanomihalou,M., Ilyina-Gragerova,G., Erwin-Cohen,R., Chrousos,G.P. and, et al. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest
  6. , Sadhu K., Reed B.I., Richardson H., Russell P. Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.
  7. , Bureik M., Rief N., Drescher R., Jungbluth A., Montenarh M., Wagner P. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein.
  8. , Livingston R.J., Rieder M.J., Chung M.-W., Ritchie T.K., Olson A.N., Nguyen C.P., Nguyen D.A., Poel C.L., Robertson P.D., Schackwitz W.S., et al. NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).
  9. , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
  10. , Wegener S., Hampe W., Herrmann D., Schaller H.C. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
Phosphate-Buffered Saline.
Immunogen affinity purified
Aff - Purified
This antibody is reactive against Human.

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