NB100-64633 Macrophages / Neutrophils antibody

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100 Tests / €360.00
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Rat anti Human Macrophages / Neutrophils YTH8.18

NB100-64633

Product Description for Macrophages / Neutrophils

Rat anti Human Macrophages / Neutrophils YTH8.18.
Presentation: Purified
Product is tested for Frozen Sections.

Properties for Macrophages / Neutrophils

Product Category Primary Antibodies
Quantity 100 Tests
Synonyms Macrophage marker
Presentation Purified
Reactivity Hu
Applications C
Clonality Monoclonal
Clone YTH8.18
Host Rat
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Human peripheral blood mononuclear cells.
Application Immunohistochemistry-Frozen, Immunohistochemistry-Frozen, Immunohistochemistry-Frozen 1:20
Background Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and promonocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becoming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). Among cells that are now recognized as macrophages are histiocytes, Kupffer cells, osteoclasts, microglial cells, synovial type A cells, interdigitating cells, and Langerhans cells (in normal tissues) and epithelioid cells and Langerhans-type and foreign-body-type multinucleated giant cells (in inflamed tissues).
Concentration 2 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
IgG purified
Buffer System:
0.09% Sodium Azide
Purity:
IgG purified
State:
Purified
Specificity
Specificity:
Recognizes all tissue macrophages, binding to a cytoplasmic epitope. In peripheral blood the stains all granulocytes and around 50% of monocytes. No staining of osteoclasts or Langerhan's cells is seen.
Species:
Human

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