GTX18326 MAPK p38 antibody

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0.2 ml / €340.00

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Rabbit anti Human, Mouse, Rat MAPK p38


Product Description for MAPK p38

Rabbit anti Human, Mouse, Rat MAPK p38.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for MAPK p38

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Synthetic peptide (Human) conjugated to KLH (C terminal).
Application WB
Background p38 is a 38 kDa Stress Activated Protein Kinase / Map Kinase (SAPK / MAPK) that is fully activated by dual phosphorylation on threonine 180 and tyrosine 182, within the activation loop. p38 MAPK plays a critical role in the initiation of G2 delay after ultraviolet radiation; gene knock-out studies have also revealed a critical role for p38 in cardiac remodeling. Downstream targets of p38 include the transcription factors ELK1 and ATF2 and the kinases MAPKAPK2 and MAPKAPK5. p38 MAPK plays a role in the production of IL-6 and is thought to stabilize erythropoietin production during hypoxic stress. It is activated by environmental stress, many pro-inflammatory cytokines and lipopolysaccharide. Dual phosphorylation by MAP2K3 and MAP2K6 is required for activation of p38 MAPK. It interacts with MAX, Cdc25B, Cdc25C and binds to the kinase interaction domain in the protein tyrosine phosphatase PTPRR; this interaction retains p38 MAPK in the cytoplasm.
Storage Keep as concentrated solution. Store at 4
Immunogen affinity purified
Buffer System:
Preservative: 0.09% Sodium Azide. Constituents: 0.1% Gelatin, PBS. pH 7.2
Immunogen affinity purified
Aff - Purified
Cross-reacts with Human, Mouse and Rat. Not yet tested in other species.

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