discontinued

NB100-75589 MAPK6 antibody

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0.05 mg / €350.00

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Chicken anti Human, Mouse, Rat MAPK6

NB100-75589

Product Description for MAPK6

Chicken anti Human, Mouse, Rat MAPK6.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for MAPK6

Product Category Primary Antibodies
Quantity 0.05 mg
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, WB
Clonality Polyclonal
Host Chicken
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
The immunogen for this antibody was a sequence from 401a.a. to 416a.a. from MAPK6(a 721a.a. long protein)
Application ELISA, Western Blot
Background MAPK6 is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. MAPK6 phosphorylates microtubule-associated protein 2 (MAP2). It may promote entry in the cell cycle.
General Readings 1. Rai,R., Mahale,A. and Saranath,D., et al.
Molecular cloning, isolation and characterisation of ERK3 gene from chewing-tobacco induced oral squamous cell carcinoma
2. Coulombe,P., Rodier,G., Bonneil,E., Thibault,P. and Meloche,S., et al.
N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome
3. Julien,C., Coulombe,P. and Meloche,S., et al.
Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression
4. Coulombe,P., Rodier,G., Pelletier,S., Pellerin,J. and Meloche,S., et al.
Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation
5. Robinson,M.J., Xu Be,B.E., Stippec,S. and Cobb,M.H., et al.
Different domains of the mitogen-activated protein kinases ERK3 and ERK2 direct subcellular localization and upstream specificity in vivo
6. , Zhu A.X., Zhao Y., Moller D.E., Flier J.S.
Cloning and characterization of p97MAPK, a novel human homolog of rat ERK-3.
7. , Meloche S., Beatty B.G., Pellerin J.
Primary structure, expression and chromosomal locus of a human homolog of rat ERK3.
8. , Saranath D., Mahale A., Rai R., Dedhia P.
ERK-3 cDNA clone isolated from human oral cancer.
9. , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
Immunogen affinity purified
Buffer System:
Phosphate-Buffered Saline.
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
This antibody is reactive against Human, mouse, rat.

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