SP5016P MAPK8 / MAPK9 pThr183/pTyr185 antibody

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Rabbit anti Human, Mouse, Rat MAPK8 / MAPK9


Product Description for MAPK8 / MAPK9

Rabbit anti Human, Mouse, Rat MAPK8 / MAPK9.
Properties: pThr183/pTyr185
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for MAPK8 / MAPK9

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms JNK-1, JNK-2, JNK-46, JNK-55, JNK1, JNK2, MAPK-8, MAPK-9, MAPK8, MAPK9, Mitogen-activated protein kinase 8/9, PRKM8, PRKM9, SAPK, Stress-activated protein kinase JNK11/JNK2, c-Jun N-terminal kinase 1/2
Presentation Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Synthetic peptide derived from human JNK 1 and 2 that contains phosphorylated threonine 183 and tyrosine 185.
Property pThr183/pTyr185
Application Western blot: 1/1000, detects an ~49 kDa protein and an ~55 kDa protein representing JNK1 and 2, respectively, from platelet-derived growth factor (PDGF) treated NIH-3T3 cell extract.
Background Cellular oncogenes, or proto-oncogenes, play pivotal roles in cellular communication pathways that regulate normal growth, development and differentiation. The cellular oncogene families fos and jun encode nuclear proteins that can function as transcription factors. The fos family of nuclear oncogenes encode cFos, FosB, (fos-related antigen) Fra1, and Fra2. The jun family member, cJun, is phosphorylated by another kinase termed cJun N-terminal kinase (JNK).
Fos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the 'leucine-zipper' motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
General Readings
  1. Prog. Biophys. Mol. Biol. 71(3-4):479-500, 1999.
Storage Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
Dulbecco's PBS (without Magnesium and Calcium), pH 7.4, 50% glycerol, containing 1 mg/mL BSA and 0.05% sodium azide as preservative.
Liquid purified IgG fraction.
This antibody detects cJun N-terminal kinase (JNK) from human, mouse, and rat tissues and cells.

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