AP05781PU-N MAPKK1 / MAPKK2 antibody

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Rabbit anti Human, Mammalia MAPKK1 / MAPKK2


Product Description for MAPKK1 / MAPKK2

Rabbit anti Human, Mammalia MAPKK1 / MAPKK2.
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for MAPKK1 / MAPKK2

Product Category Primary Antibodies
Quantity 50 µg
Synonyms MEK1, MEK2, MKK1, MKK2, PRKMK1, PRKMK2
Presentation Purified
Reactivity Hu, Mam
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Keyhole Limpet Haemocyanin conjugated synthetic peptide corresponding to amino acids 33-53 of human MEK 1.
Application Western Blot: 0.5µg/ml; detects a band of approximately 45kDa in RAJI human Burkitt Lymphoma whole cell lysates under reducing conditions.
Background MEK1 and MEK2 play a critical role in the evolutionarily conserved MAP kinase signalling cascade controlling cell growth and differentiation.
MEK 1 and MEK 2 are activated through the phosphorylation of serine residues Ser218 and Ser222 by Raf, which then act together to phosphorylate ERK (mitogen-activated protein kinase) on a threonine and tyrosine residue. The activated ERK then moves to the nucleus where it activates transcription factors involved in the regulation of gene expression.
Caution (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Concentration 1.0mg/ml
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
Phosphate buffered saline containing 0.09% Sodium Azide (NaN3) 2% Bovine Serum Albumin
Liquid purified IgG
AHP1584 specifically recognises MEK 1 and MEK 2, also known as MAPKK1 and MAPKK2 respectively, related dual specificity protein kinases and members of the STE serine/threonine protein kinase family.

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