TA306400 MAVS (Center) antibody

Rabbit Polyclonal VISA Antibody

See related secondary antibodies

Search for all "MAVS"

0.1 mg / €371.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat MAVS

TA306400

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  • TA306400
  • TA306400

Product Description for MAVS

Rabbit anti Human, Mouse, Rat MAVS.
Properties: (Center)
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot.

Properties for MAVS

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms CARD adapter inducing interferon-beta, Cardif, IPS1, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter, nterferon-beta promoter stimulator protein 1
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications E, P, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
Q7Z434
Immunogen:
VISA antibody was raised against a 17 amino acid peptide from near the center of human VISA.
GeneID:
57506
Property Center
Add. information Blocking peptide available: AP30985CP-N
Application ELISA.
Western blot: 0.5 – 1 μg/ml.
Immunohistochemistry on paraffin sections.
Background Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
General Readings
  1. Seth RB, Sun L, Chen ZJ. Antiviral innate immunity pathways. Cell Res. 2006 Feb;16(2):141-7. PubMed PMID: 16474426.
  2. Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB. VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell. 2005 Sep 16;19(6):727-40. PubMed PMID: 16153868.
  3. Meylan E, Curran J, Hofmann K, Moradpour D, Binder M, Bartenschlager R, et al. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature. 2005 Oct 20;437(7062):1167-72. Epub 2005 Sep 21. PubMed PMID: 16177806.
Storage Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affinity chromatography
Buffer System:
PBS containing 0.02% sodium azide
State:
Liquid Ig fraction
Aff - Purified
Species Reactivity
Species reactivity (tested):
Human, mouse, rat
Specificity
Specificity:
This antibody detects MAVS at Center.

Accessory Products

Proteins and/or Positive Controls

Proteins for MAVS (6 products)

Catalog No. Species Pres. Purity   Source  

MAVS

MAVS Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

MAVS (1-513, His-tag)

MAVS Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €730.00
  OriGene Technologies GmbH

MAVS (1-513, His-tag)

MAVS Human Purified > 85 % by SDS - PAGE E. coli
10 µg / €300.00
  OriGene Technologies GmbH

MAVS

MAVS Human
  Abnova Taiwan Corp.

MAVS

MAVS Human Purified
  Abnova Taiwan Corp.

MAVS

MAVS Human Purified
  Abnova Taiwan Corp.

Positive controls for MAVS (2 products)

Catalog No. Species Pres. Purity   Source  

MAVS overexpression lysate

MAVS overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

VISA 293T Cell Transient Overexpression Lysate(Denatured)

VISA 293T Cell Transient Overexpression Lysate(Denatured)
  Abnova Taiwan Corp.
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