NB100-81658 MBD4 antibody

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Rabbit anti Human MBD4


Product Description for MBD4

Rabbit anti Human MBD4.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for MBD4

Product Category Primary Antibodies
Quantity 0.02 mg
Presentation Aff - Purified
Reactivity Hu
Applications IP, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

The epitope recognized by this antibody maps to a region between residue 1 and 50 of human methyl-CpG binding domain protein 4 using the numbering given in entry NP_003916.1 (GeneID 8930).
Application Western Blot 1:2000-1:10000, immunoprecipitation 2-5 mcg/mg lysate
Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Concentration 0.2 mg/ml
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
Tris-buffered Saline containing 0.1% BSA
Immunogen affinity purified
Aff - Purified

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