discontinued

NB100-81659 MBD4 antibody

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0.1 mg / €380.00

Quick Overview

Rabbit anti Human MBD4

NB100-81659

Product Description for MBD4

Rabbit anti Human MBD4.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation.

Properties for MBD4

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications IP
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
The epitope recognized by this antibody maps to a region between residue 250 and 300 of human methyl-CpG binding domain protein 4 using the numbering given in entry NP_003916.1 (GeneID 8930).
Application immunoprecipitation 2-5 mcg/mg lysate
Background DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Concentration 1 mg/ml
Storage Store at 4C. Do not freeze.
Format
Purification:
Immunogen affinity purified
Buffer System:
Tris-citrate/phosphate buffer, pH 7 to 8
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Species:
Human.

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