TA326905 MCM3 antibody

MCM3 Rabbit Polyclonal Antibody

See related secondary antibodies

Search for all "MCM3"

0.1 mg / €325.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Human, Mouse, Rat MCM3

TA326905

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Product Description for MCM3

Rabbit anti Human, Mouse, Rat MCM3.
Presentation: Purified

Properties for MCM3

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms DNA polymerase alpha holoenzyme-associated protein P1, DNA replication licensing factor MCM3, P1-MCM3, P102 protein, RLF subunit beta, mini-chromosome maintenance protein 3
Presentation Purified
Reactivity Hu, Ms, Rt
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P25205
Immunogen:
Recombinant protein of human MCM3.
GeneID:
4172
Application WB 1:500 - 1:2000
IHC 1:50- 1:200
IF 1:50- 1:200
Background The minichromosome maintence (MCM) 2-7 proteins are a family of six related proteins required for the initiation and elongation of D replication. MCM2-7 bind together to form the heterohexameric MCM complex that is thought to act as a replicative helicase at the D replication fork. This complex is also a key component of the pre-replication complex (pre-RC). Cdc6 and CDT1 recruit the MCM complex to the origin recognition complex (ORC) during late mitosis/early G1 phase forming the pre-RC and licensing the D for replication. Phosphorylation of the MCM2, MCM3, MCM4, and MCM6 subunits appears to regulate MCM complex activity and the initiation of D synthesis. MCM proteins are removed during D replication, causing chromatin to become unlicensed through inhibition of pre-RC reformation. Licensing of the chromatin permits the D to replicate only once per cell cycle, thereby helping to ensure that genetic alterations and malignt cell growth do not occur. Studies have shown that the MCM complex is involved in checkpoint control by protecting the structure of the replication fork and assisting in restarting replication by recruiting checkpoint proteins after arrest.
Format
Purification:
Affinity purification
Buffer System:
Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
State:
Purified

Accessory Products

Proteins and/or Positive Controls

Proteins for MCM3 (3 products)

Catalog No. Species Pres. Purity   Source  

MCM3

MCM3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

MCM3

MCM3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

MCM3

MCM3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

Positive controls for MCM3 (2 products)

Catalog No. Species Pres. Purity   Source  

MCM3 Lysate

Western Blot: MCM3 Lysate [NBL1-12951] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for MCM3
  Novus Biologicals Inc.

MCM3 overexpression lysate

MCM3 overexpression lysate
0.1 mg / €280.00
  OriGene Technologies, Inc.
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