NB100-74576 MCPH1 antibody

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Goat anti Mouse MCPH1


Product Description for MCPH1

Goat anti Mouse MCPH1.
Presentation: Aff - Purified
Product is tested for Enzyme Immunoassay, Western blot / Immunoblot.

Properties for MCPH1

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Ms
Applications E, WB
Clonality Polyclonal
Host Goat
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide, C-KEKRENLSPTSSQ, representing the internal region of the sequence according to NP_078872.2
Application ELISA 1:32000, Western Blot 0.1-0.3ug/ml
Background BRIT1 (BRCT-repeat inhibitor of hTERT expression) contains two BRCT domains in the C terminus. It was identified in a screen for negative regulators of hTERT (human telomerase) expression. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Defects in BRIT1 are the cause of primary microcephaly 1 (MCPH1)
Concentration 0.5 mg/ml
General Readings Chaplet M, et al. BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle. 2006 Nov;5(22):2579-83. Epub 2006 Nov 15. Review. PMID: 17172830
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
Tris-saline [pH7.3] with 0.5% BSA
Immunogen affinity purified
Aff - Purified
Mouse. Expected from sequence similarity: Human, Mouse, Rat, Dog

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