NSB452 MEK 1/2 antibody

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Rabbit anti Human, Mouse, Rat MEK 1/2

Product Description for MEK 1/2

Rabbit anti Human, Mouse, Rat MEK 1/2.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for MEK 1/2

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide (Human) derived from a region of human MEK 1 + 2 that contains serine 222. The sequence is conserved in many species including mouse, rat, chimp, chicken, frog, and others.
Add. information Research Areas: Cancer
Application Western Blot, This antibody is useful for Western Blot., Western Blot 0.1-1.0 ug/ml
Background Microtubule-associated protein kinase kinase 1 + 2 (MEK 1 + 2 or MAPKK 1+ 2) are members of a tyrosine/threonine protein kinase family that activate the ERK 1 + 2/MAPK enzymes by phosphorylating both residues within the threonine
Concentration 0.5 mg/ml
General Readings General / background references:Lin CC et al. Thrombin-stimulated cell proliferation mediated through activation of Ras/Raf/MEK/MAPK pathway in canine cultured tracheal smooth muscle cells. Cell Signal 14:265-75 (2002). PubMed PMID: 11812655
Jin K et al. MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad. J Neurochem 80:119-25 (2002). PubMed PMID: 11796750
Takahashi H et al. Expression of human cystatin A by keratinocytes is positively regulated via the Ras/MEKK1/MKK7/JNK signal transduction pathway but negatively regulated via the Ras/Raf-1/MEK1/ERK pathway. J Biol Chem 276:36632-8 (2001). PubMed PMID: 11451947
Kolch W Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351 Pt 2:289-305 (2000). PubMed PMID: 11023813
Storage Store at -80C. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
0.05% Sodium Azide
Immunogen affinity purified
Aff - Purified
MEK 1 + 2 [Ser222]
Human, Mouse, Rat

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