NSB470 MEK 3/6 antibody

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Rabbit anti Human MEK 3/6

Product Description for MEK 3/6

Rabbit anti Human MEK 3/6.
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for MEK 3/6

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Aff - Purified
Reactivity Hu
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide (Human)derived from a region of human MEK 3 that contains serine 189 and threonine 193.
Add. information Research Areas: Cancer
Application Western Blot, WB: Use at a concentration of 0.1 - 1.0 ug/ml. Predicted molecular weight: 39.3 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user., Western Blot
Background Mitogen Activated Protein Kinase Kinases 3 and 6 (MEK 3/6 or MKK 3/6) are 42 kDa members of a tyrosine/threonine protein kinase family that activate p38, which is part of the inflammation/stress signaling pathway. Phosphorylation of MEK3 and 6 by MEKK1 on serine 189 and threonine 193 (serine 207 and threonine 211 for MEK6) in the catalytic domain activates the proteins and enables them to phosphorylate p38.
Concentration 0.5 mg/ml
General Readings General / background references:Chen Z & Cobb MH Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. J Biol Chem 276:16070-5 (2001). PubMed PMID: 11279118
Nishio H et al. Immunolocalization of the mitogen-activated protein kinase signaling pathway in Hassall's corpuscles of the human thymus. Acta Histochem 103:89-98 (2001). PubMed PMID: 11252631
Browning DD et al. Activation of p38 mitogen-activated protein kinase by lipopolysaccharide in human neutrophils requires nitric oxide-dependent cGMP accumulation. J Biol Chem 274:537-42 (1999). PubMed PMID: 9867877
Stein B et al. Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. J Biol Chem 271:11427-33 (1996). PubMed PMID: 8626699
Immunogen affinity purified
Buffer System:
0.05% Sodium Azide
Immunogen affinity purified
Aff - Purified
This reacts with MEK 3 and MEK 6 (93% homologous). This shows some cross-reactivity with MEK 4 when tested in a system with high MEK 4 expression levels. It does not react with any other MEK isoforms.

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