AM32140SU-N Melanoma Marker antibody

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1 ml / €310.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human Melanoma Marker 2g12


Product Description for Melanoma Marker

Mouse anti Human Melanoma Marker 2g12.
Presentation: Supernatant
Product is tested for Western blot / Immunoblot, Immunocytochemistry/Immunofluorescence.

Properties for Melanoma Marker

Product Category Primary Antibodies
Quantity 1 ml
Presentation Supernatant
Reactivity Hu
Applications ICC/IF, WB
Clonality Monoclonal
Clone 2g12
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Application Immunoblotting
Immunocytochemistry techniques. 
Working Dilution: starting at 1/10.
Background Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites. Malignant melanoma underlies the majority of skin cancer-related deaths. Melanoma originates in melanocytes, the cells which produce the pigment melanin, which colors human skin, hair, and eyes and is heavily concentrated in most moles. Epidemiologic studies suggest that exposure to ultraviolet radiation is one of the major contributors to the development of melanoma. The four most common types of melanoma in the skin are superficial spreading melanomas, which evolve from a precursor lesion (usually a dysplastic nevus); nodular melanomas, the most aggressive form; acral lentiginous melanomas, which are seen on the palms, soles and under the nails; and Lentigo malignas, which consist of malignant cells but do not show invasive growth.
General Readings
  1. van Duinen SG, Ruiter DJ, Hageman P, Vennegoor C, Dickersin GR, Scheffer E, et al. Immunohistochemical and histochemical tools in the diagnosis of amelanotic melanoma. Cancer. 1984 Apr 1;53(7):1566-73. PubMed PMID: 6365305.
  2. Bonetti F, Colombari R, Manfrin E, Zamboni G, Martignoni G, Mombello A, et al. Breast carcinoma with positive results for melanoma marker (HMB-45). HMB-45 immunoreactivity in normal and neoplastic breast. Am J Clin Pathol. 1989 Oct;92(4):491-5. PubMed PMID: 2552794.
  3. Lin CS. Melanoma marker and breast carcinoma. Am J Clin Pathol. 1990 Nov;94(5):669-70. PubMed PMID: 2288610.
  4. Fernando SS, Johnson S, Bäte J. Immunohistochemical analysis of cutaneous malignant melanoma: comparison of S-100 protein, HMB-45 monoclonal antibody and NKI/C3 monoclonal antibody. Pathology. 1994 Jan;26(1):16-9. PubMed PMID: 8165017.
  5. Salazar-Onfray F, López M, Lundqvist A, Aguirre A, Escobar A, Serrano A, et al. Tissue distribution and differential expression of melanocortin 1 receptor, a malignant melanoma marker. Br J Cancer. 2002 Aug 12;87(4):414-22. PubMed PMID: 12177778. (Free PMC Article available, 5 images available)
  6. Stoitchkov K, Letellier S, Garnier JP, Bousquet B, Tsankov N, Morel P, et al. Evaluation of the serum L-dopa/L-tyrosine ratio as a melanoma marker. Melanoma Res. 2003 Dec;13(6):587-93. PubMed PMID: 14646622.
  7. Guerquin-Kern, J.L., Hillion, F., Madelmont, J.C., Labarre, P., Papon, J. and Croisy, A. 2004. Ultra-structural cell distribution of the melanoma marker iodobenzamide: improved potentiality of SIMS imaging in life sciences. Biomed. Eng. Online 3: 10.
  8. Balch CM, Cascinelli N. Sentinel-node biopsy in melanoma. N Engl J Med. 2006 Sep 28;355(13):1370-1. PubMed PMID: 17005955.
  9. Dunbar, R., Findlay, M. and Stevens, G. 2006. Melanoma control: few answers, many questions. N.Z. Med. J. 119: U2172.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
0.09% Sodium Azide
Tissue Culture Supernatant
This antibody will react with the 240-270 kDa membrane antigen and is an important marker for melanoma studies.

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