TA500381 Melastatin-4 antibody

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0.1 ml / €379.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.


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Mouse anti Canine, Human, Monkey Melastatin-4 OTI10H5


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Product Description for Melastatin-4

Mouse anti Canine, Human, Monkey Melastatin-4 OTI10H5.
Presentation: Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for Melastatin-4

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Calcium-activated non-selective cation channel 1, LTRPC4, Long transient receptor potential channel 4, Melastatin-4, TRPM4, Transient receptor potential cation channel subfamily M member 4
Presentation Purified
Reactivity Can, Hu, Mky
Applications P, WB
Clonality Monoclonal
Clone OTI10H5
Host Mouse
Isotype IgG1
Shipping to Europe, USA/Canada
PDF datasheet View Datasheet
Manufacturer OriGene Technologies, Inc.

Datasheet Extract

Swiss Prot Num:
Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Application WB 1:5000~10000
IHC 1:50
Background Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations ((+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhil cortex, dorsal root and vomerosal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Product Citations
Originator or purchased from resellers:
  1. Becerra A, Echeverría C, Varela D, Sarmiento D, Armisén R, Nuñez-Villena F, et al. Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death. Cardiovasc Res. 2011 Sep 1;91(4):677-84. doi: 10.1093/cvr/cvr135. Epub 2011 May 11. PubMed PMID: 21565835.
  2. Sarmiento D, Montorfano I, Cerda O, Cáceres M, Becerra A, Cabello-Verrugio C, et al. Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel. Microvasc Res. 2015 Mar;98:187-96. doi: 10.1016/j.mvr.2014.02.001. Epub 2014 Feb 9. PubMed PMID: 24518820.
Purified from mouse ascites fluids by affinity chromatography
Buffer System:
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Accessory Products

Proteins and/or Positive Controls

Proteins for Melastatin-4 (1 products)

Catalog No. Species Pres. Purity   Source  


Melastatin-4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Positive controls for Melastatin-4 (2 products)

Catalog No. Species Pres. Purity   Source  

TRPM4 Lysate

TRPM4 Lysate
0.1 mg / €620.00
  Novus Biologicals Inc.

TRPM4 overexpression lysate

TRPM4 overexpression lysate
0.1 mg / €480.00
  OriGene Technologies, Inc.
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