AP05199PU-N mGluR2/3 antibody

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10 Blots / €460.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

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Rabbit anti Rat mGluR2/3

Product Description for mGluR2/3

Rabbit anti Rat mGluR2/3.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for mGluR2/3

Product Category Primary Antibodies
Quantity 10 Blots
Synonyms GRM2, GRM3, Metabotropic glutamate receptor 2, Metabotropic glutamate receptor 2/3, Metabotropic glutamate receptor 3, mGlu 2, mGlu 3, mGlu2
Presentation Aff - Purified
Reactivity Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Synthetic peptide derived from the C-terminal of the mGluR2 and mGluR3.
Application Western Blot: 1:1000.
Immunohistochemistry on frozen sections: 1:500.
Background The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR2 subunit has been shown to be required for long-term potentiation at the mossy fiber input in the hippocampus (Yokoi et al., 1996).
Concentration Lot specific
General Readings 1. Bhattacharya M, Babwah AV, Godin C, Anborgh PH, Dale LB, Poulter MO, Ferguson SSG (2004)
Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor
endocytosis. J Neurosci 24:8752–8761.
2. Blaabjerg M, Fang LW, Zimmer J, Baskys A (2003) Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. Exp Neurol 183:573 - 580.
3. Francesconi W, Cammalleri M, Sanna PP (2004) The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res 1022:12 - 18.
4. Wilson RI, Nicoll RA (2001) Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature (London) 410:588 - 592.
Storage Ship on dry ice. Store (in aliquots) at -20°C to -70°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
HEPES (pH 7.5) solution containing 150 mM NaCl, 100 µg per ml BSA and 50% glycerol
Aff - Purified
Liquid purified Ig
Aff - Purified
This antibody reacts to Metabotropic Glutamate Receptor 2/3 (mGluR2/3).
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