AP08692PU-N mGluR2/3 (C-term) antibody

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0.1 ml / €380.00
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Rabbit anti Bovine, Canine, Human, Mouse, Rat, Zebrafish mGluR2/3

Product Description for mGluR2/3

Rabbit anti Bovine, Canine, Human, Mouse, Rat, Zebrafish mGluR2/3.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for mGluR2/3

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms GRM2, GRM3, MGLUR2, MGLUR3, Metabotropic Glutamate Receptor 2/3
Presentation Aff - Purified
Reactivity Bov, Can, Hu, Ms, non-Human Primates, Rt, Ze
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Peptide from the C-terminal region of Rat mGluR2 and Rat mGluR3.
Property C-term
Application Dot blot: 1/1000.
Western blot: 1/1000.
Immunohistochemistry: 1/500.
Background The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR2 subunit has been shown to be required for long-term potentiation at the mossy fiber input in the hippocampus (Yokoi et al., 1996).
General Readings
  1. Bhattacharya M, Babwah AV, Godin C, Anborgh PH, Dale LB, Poulter MO, et al. Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J Neurosci. 2004 Oct 6;24(40):8752-61. PubMed PMID: 15470141.
  2. Francesconi W, Cammalleri M, Sanna PP. The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res. 2004 Oct 1;1022(1-2):12-8. PubMed PMID: 15353208.
  3. Wilson RI, Nicoll RA. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature. 2001 Mar 29;410(6828):588-92. PubMed PMID: 11279497.
  4. Yokoi M, Kobayashi K, Manabe T, Takahashi T, Sakaguchi I, Katsuura G, et al. Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 1996 Aug 2;273(5275):645-7. PubMed PMID: 8662555.
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Affnity Chromatography.
Buffer System:
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
State:
Liquid purified Ig fraction.
Aff - Purified
Species Reactivity
Species reactivity (expected):
Bovine, Canine, Human, Mouse, Zebrafish and non-Human Primates.
Species reactivity (tested):
Rat.
Specificity
Specificity:
This antibody recognizes the ~110k monomer and the ~220k dimer of mGluR2 and mGluR3. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to generate the antibody.

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