AP08693PU-N mGluR5/1a (C-term) antibody

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0.1 ml / €370.00
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Quick Overview

Rabbit anti Human, Mouse, Rat mGluR5/1a

Product Description for mGluR5/1a

Rabbit anti Human, Mouse, Rat mGluR5/1a.
Properties: (C-term)
Presentation: Aff - Purified
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for mGluR5/1a

Product Category Primary Antibodies
Quantity 0.1 ml
Synonyms GRM1A, GRM5, MGLUR1a, MGLUR5, Metabotropic Glutamate Receptor 5/1a
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications C, WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Peptide from the C-terminal region of rat mGluR5 and rat mGluR1a.
Property C-term
Application Western blot: 1/1000.
Immunohistochemistry: 1/500.
Background The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).
General Readings
  1. Bhattacharya M, Babwah AV, Godin C, Anborgh PH, Dale LB, Poulter MO, et al. Ral and phospholipase D2-dependent pathway for constitutive metabotropic glutamate receptor endocytosis. J Neurosci. 2004 Oct 6;24(40):8752-61. PubMed PMID: 15470141.
  2. Blaabjerg M, Fang L, Zimmer J, Baskys A. Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. Exp Neurol. 2003 Oct;183(2):573-80. PubMed PMID: 14552898.
  3. Francesconi W, Cammalleri M, Sanna PP. The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res. 2004 Oct 1;1022(1-2):12-8. PubMed PMID: 15353208.
  4. Wilson RI, Nicoll RA. Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses. Nature. 2001 Mar 29;410(6828):588-92. PubMed PMID: 11279497.
Storage Store the antibody undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Affinity Chromatography.
Buffer System:
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% Glycerol.
Liquid purified Ig fraction.
Aff - Purified
Species Reactivity
Species reactivity (expected):
Human and Mouse.
Species reactivity (tested):
This antibody is specific for the ~125k monomer and the ~250k dimers of mGluR5 and mGluR1. Immunolabeling is blocked by preadsorption of antibody with the peptide used as antigen to generate the antibody.

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