NB100-64952 MHC Class I H-2 (b,d,q,h4,m,w16) antibody

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0.125 mg / €360.00
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Quick Overview

Rat anti Mouse MHC Class I H-2 ER-HR52

NB100-64952

Product Description for MHC Class I H-2

Rat anti Mouse MHC Class I H-2 ER-HR52.
Properties: (b,d,q,h4,m,w16)
Presentation: Purified
Product is tested for Frozen Sections, Flow Cytometry, Paraffin Sections.

Properties for MHC Class I H-2

Product Category Primary Antibodies
Quantity 0.125 mg
Presentation Purified
Reactivity Ms
Applications C, F, P
Clonality Monoclonal
Clone ER-HR52
Host Rat
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Immunogen:
Adherent FI (CBAXBL) bone marrow stromal cells
Property b,d,q,h4,m,w16
Isotype control SM15P, SM15PX
Add. information Research Areas: Immunology
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, This antibody is useful for Immunohistochemistry-Frozen, flow cytometry / FACS analysis, flow cytometry / FACS analysis 1/50 - 1/200, Immunohistochemistry-Frozen
Background MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.
Concentration 1 mg/ml
General Readings
  1. Medana, I. et.al. (2001) Transection of major histocompatibility complex Class I – induced neuritis by cytotoxic T lymphocytes. Am J Pathol.159:809 – 815.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Format
Purification:
protein G purified
Buffer System:
0.09% Sodium Azide
Purity:
protein G purified
State:
Purified
Specificity
Specificity:
NB100-64952 recognizes a polymorphic determinant on the murine MHC (major histocompatibility complex) class I molecule. In the mouse, the MHC class I molecule is expressed on the cell surface of all nucleated cells but expression levels may differ according to cell type. Clone ER-MP52 specifically recognizes mouse strains with the haplotypes H-2b,w16 and H-2 d,p,q. Mouse strains with the haplotypes H-2 f,r,s,w17,w23,w27 show weak reactivity with this antibody.
Species:
Mouse

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