BM2243F MHC Class I H-2Kd,Dd,q,u antibody

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Mouse anti Mouse MHC Class I H-2Kd,Dd,q,u A5A1-Do4


Product Description for MHC Class I H-2Kd,Dd,q,u

Mouse anti Mouse MHC Class I H-2Kd,Dd,q,u A5A1-Do4.
Presentation: FITC
Product is tested for Flow Cytometry.

Properties for MHC Class I H-2Kd,Dd,q,u

Product Category Primary Antibodies
Quantity 0.5 mg
Synonyms Class I major histocompatibility antigen H 2Kd
Presentation FITC
Reactivity Ms
Applications F
Clonality Monoclonal
Clone A5A1-Do4
Host Mouse
Isotype IgG3
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Isotype control AM03097FC-N
Application Cell Surface Analysis.
Genetic Mapping.
Allele specific cell elimination.
FACS analysis: Use 1 µg to stain 1x10e6 cells in Flow Cytometry.
Complement-dependent microcytoxicity killing.
Functional Studies: blocking CTLs (class I-specific).
Background MHC Class I H2 Kd is involved in the presentation of foreign antigens to the immune system. The ''classical'' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant Beta2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny.
Concentration 0.5 mg/ml (OD280 nm)
General Readings
  1. Hauptfeld, V. (1984), Immunogenetics, 19: 169.
Storage Store the antibody undiluted at 2-8°C.
This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Protein A Chromatography.
Buffer System:
0.01 M PBS pH 7.2, containing 2.0 mM EDTA, 1% BSA as stabilizer and 0.09% Sodium Azide as preservative.
Liquid purified Ig fraction.
Species Reactivity
Species reactivity (tested):
This antibody detects classical mouse class I antigen; MW 45 kDa ubiquitously distributed.
Present on 100% of T-Cells, B-Cells, Erythrocytes, Macrophages, Endothelial and Epithelial tissue.
Positive with this antibody are strains of independent haplotypes H-2KdDd,q,u.
Positive are intra-H-2 recombinants carrying alleles Kd, Dd, Ld, Dq.
Strains carrying all other alleles are negative.

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