SM477 MHC Class II DQ beta / HLA-DQB antibody

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Mouse anti Sheep MHC Class II DQ beta / HLA-DQB VPM41


Product Description for MHC Class II DQ beta / HLA-DQB

Mouse anti Sheep MHC Class II DQ beta / HLA-DQB VPM41.
Presentation: Supernatant
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunoprecipitation, Flow Cytometry.

Properties for MHC Class II DQ beta / HLA-DQB

Product Category Primary Antibodies
Quantity 2 ml
Synonyms DQ beta chain, HLA class II histocompatibility antigen, MHC class II antigen DQB1
Presentation Supernatant
Reactivity Sh
Applications C, E, F, IP
Clonality Monoclonal
Clone VPM41
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Acid treated ovine MHC Class II.
Application ELISA. 
Flow Cytometry. 
Immunohistochemistry on Frozen Sections. 
Clone VPM41 has been reported as being suitable for use in Western blotting.
Background The major histocompatibility complex (MHC) is a cluster of genes some of which are important in the immune response to infections. In sheep, this complex is referred to as the ovine leukocyte antigen (OLA) region. There are 2 major types of MHC class IIa molecules encoded by the OLA which are DR and DQ each composed of an alpha and beta chain.
General Readings
  1. Dutia BM, Hopkins J, Allington MP, Bujdoso R, McConnell I. Characterization of monoclonal antibodies specific for alpha- and beta-chains of sheep MHC class II. Immunology. 1990 May;70(1):27-32. PubMed PMID: 2354860. (Free PMC Article available)
  2. Ballingall KT, Wright H, Redmond J, Dutia BM, Hopkins J, Lang J, et al. Expression and characterization of ovine major histocompatibility complex class II (OLA-DR) genes. Anim Genet. 1992;23(4):347-59. PubMed PMID: 1503274.
  3. Ballingall KT, Dutia BM, Hopkins J, Wright H. Analysis of the fine specificities of sheep major histocompatibility complex class II-specific monoclonal antibodies using mouse L-cell transfectants. Anim Genet. 1995 Apr;26(2):79-84. PubMed PMID: 7733511.
Storage Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Buffer System:
0.2M Tris/HCl pH7.4 and 5-10% Foetal Calf Serum
0.01% Sodium Azide
Liquid Tissue Culture Supernatant
Species Reactivity
Species reactivity (tested):
This antibody recognizes a polymorphic epitope on the beta chain of Sheep MHC Class II DQ molecules, which are constitutively expressed on antigen presenting cells such as dendritic cells, B lymphocytes, monocytes, macrophages, activated T lymphocytes and may be induced on a range of other cell types by interferon gamma.

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