NB100-65422 MHC Class II DQ DR antibody

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Mouse anti Sheep MHC Class II DQ DR 28.1


Product Description for MHC Class II DQ DR

Mouse anti Sheep MHC Class II DQ DR 28.1.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Flow Cytometry, Immunoprecipitation, Paraffin Sections.

Properties for MHC Class II DQ DR

Product Category Primary Antibodies
Quantity 0.125 mg
Presentation Aff - Purified
Reactivity Sh
Applications C, F, IP, P
Clonality Monoclonal
Clone 28.1
Host Mouse
Isotype IgG1
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Ovine alveolar macrophages
Add. information Research Areas: Immunology
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, immunoprecipitation, Immunohistochemistry-Frozen, Immunoprecipitation and Flow cytometry / FACS analysis, flow cytometry / FACS analysis 1:100, immunoprecipitation , Immunohistochemistry-Frozen
Background MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
Aff - Purified
NB100-65422 recognizes a polymorphic epitope on ovine MHC class II DQ and DR molecules. In recent work, this clone was found to recognize ovine MHC II transfectants DQ - T28.1, DQ - T26.2 and DR - T31.3 but not DR - T8.1. (Ballingall.K. et al. 1995). Ovine MHC class II antigens are expressed on several cell types, including B cells, activated T cells, monocytes, macrophages and dendritic cells. * This clone has been reported to react with paraffin-embedded material following alcohol fixation (1). Please refer to reference Sainte Marie et al for more information.

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