NB100-65423 MHC Class II DQ DR antibody

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Mouse anti Bovine, Goat, Human, Sheep MHC Class II DQ DR 49.1

Product Description for MHC Class II DQ DR

Mouse anti Bovine, Goat, Human, Sheep MHC Class II DQ DR 49.1.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Flow Cytometry, Immunoprecipitation, Paraffin Sections.

Properties for MHC Class II DQ DR

Product Category Primary Antibodies
Quantity 0.125 mg
Presentation Aff - Purified
Reactivity Bov, Gt, Hu, Sh
Applications C, F, IP, P
Clonality Monoclonal
Clone 49.1
Host Mouse
Isotype IgG2a
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Add. information Research Areas: Immunology
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, immunoprecipitation, Immunohistochemistry-Frozen, Immunoprecipitation and Flow cytometry / FACS analysis, flow cytometry / FACS analysis 1:50 - 1:200, immunoprecipitation , Immunohistochemistry-Frozen
Background MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
Aff - Purified
NB100-65423 recognizes a polymorphic epitope on ovine MHC class II DQ and DR molecules. In recent work, this clone was found to recognize ovine MHC transfectants DQ - T28.1, DR - T8.1 DR - T31.3, but not DQ - T26.2. (Ballingall. K. et al. 1995). The expression of ovine MHC class II molecules is restricted to B cells, activated T cells, monocytes, macrophages, dendritic cells and some endothelial and epithelial cells. *This clone has been reported to react with paraffin-embedded material following alcohol fixation. Please refer to reference Sainte Marie et al for information about this protocol.
Bovine, Goat, Human, Sheep

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