NB100-64961 MHC Class II (I-A k,b,d,q,r) antibody

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Rat anti Mouse MHC Class II (I-A k,b,d,q,r) ER-TR3


Product Description for MHC Class II (I-A k,b,d,q,r)

Rat anti Mouse MHC Class II (I-A k,b,d,q,r) ER-TR3.
Presentation: Aff - Purified
Product is tested for Frozen Sections, Flow Cytometry, Paraffin Sections.

Properties for MHC Class II (I-A k,b,d,q,r)

Product Category Primary Antibodies
Quantity 0.125 mg
Presentation Aff - Purified
Reactivity Ms
Applications C, F, P
Clonality Monoclonal
Clone ER-TR3
Host Rat
Isotype IgG2b
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Isolated C3H thymic stromal cells
Application flow cytometry / FACS analysis, Immunohistochemistry-Frozen, Immunohistochemistry-Frozen and Flow cytometry / FACS analysis, Immunohistochemistry-Frozen flow cytometry / FACS analysis
Background MHC Class II antigens are heterodimers consisting of one alpha chain(31-34kD) and one beta chain (26-29kD). The family of monoclonal antibodies (ER-TR 3, ER-TR 2, ER-TR 1) detect MHC class II antigens encoded by the murine Ia region of the H-2 complex, corresponding to the human HLA-DR region. MHC Class II antigens are a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells, macrophages) and offer new possibilities for studying the development of T helper cells since these antibodies also stain stromal cells in the thymus. MHC Class II antigens are also inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
protein G purified
Buffer System:
0.09% Sodium Azide
protein G purified
Aff - Purified
NB100-64961 recognizes a polymorphic determinant on the murine MHC (major histocompatibility complex) class II molecule. In the mouse, MHC class II molecules are expressed by dendritic cells, B-cells and macrophages. In thymus tissues, clone ER-TR3 stains cortical and medullary stromal cells. Clone ER-TR3 specifically recognizes mouse strains with the haplotypes I-A k,b,d,q,r. Mouse strains with the haplotypes I-A s,f are not recognized by this antibody.

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