BP157 Microtubule Associated Protein 2 (MAP2 + Tau) antibody

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0.2 ml / €410.00
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Rabbit anti Bovine Microtubule Associated Protein 2 (MAP2 + Tau)

BP157

Product Description for Microtubule Associated Protein 2 (MAP2 + Tau)

Rabbit anti Bovine Microtubule Associated Protein 2 (MAP2 + Tau).
Presentation: Serum
Product is tested for Frozen Sections, Western blot / Immunoblot.

Properties for Microtubule Associated Protein 2 (MAP2 + Tau)

Product Category Primary Antibodies
Quantity 0.2 ml
Presentation Serum
Reactivity Bov
Applications C, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Immunogen:
Native, from brain
Application Immunohistochemistry on frozen sections (1:5 - 1:30).
Western blot (Recognises mainly the MAP2 protein (280 kD) and to a lesser extent the Tau protein (60 kD) in blotting using bovine brain extract. When testing against rat brain extract this antibody shows strong bands at 60 kD and fainter bands at the higher molecular weights. This could be due to differences in the sample preparation).
Background MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20, MAP2a appears. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D-like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in other types. MAP2 is known to promote microtubule assembly and to form side-arms on microtubules. It also interacts with neurofilaments, actin, and other elements of the cytoskeleton.
Concentration 25.5 mg/ml
General Readings
  1. (0) J. Neuroscience., Feb 1999; 19:1324-1334
Storage Store the antibody at -20 °C. Ship at 2 - 8 °C.
Avoid repeated freezing and thawing.
Shelf life: One year from despatch.
Format
Purification:
Prepared by Ammonium Sulphate fractionation
Buffer System:
PBS, pH 7.2, 0.09 % Sodium Azide
State:
Liquid Ig fraction
Serum
Specificity
Specificity:
This antibody detects Microtubule Associated Protein 2 (+ tau).
Species:
Bovine

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