DDX0430P-50 MIP3 alpha / CCL20 antibody

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50 µg / €340.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Mouse anti Human, Macaque MIP3 alpha / CCL20 319F6.07

DDX0430P-50

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  • DDX0430P-50
  • DDX0430P-50

Product Description for MIP3 alpha / CCL20

Mouse anti Human, Macaque MIP3 alpha / CCL20 319F6.07.
Presentation: Purified
Product is tested for Frozen Sections, Enzyme Immunoassay, ELISA (capture), Functional assay.

Properties for MIP3 alpha / CCL20

Product Category Primary Antibodies
Target Category
Quantity 50 µg
Synonyms Beta chemokine exodus-1, C-C motif chemokine 20, CC chemokine LARC, CCL20, DC marker, Dendritic Cell Marker, Exodus-1, LARC, Liver and activation-regulated chemokine, MIP-3 alpha, MIP3A, Macrophage inflammatory protein 3 alpha, SCYA20, Small-inducible cytokine A20
Presentation Purified
Reactivity Hu, Macaque
Applications C, E, E(capture), FN
Clonality Monoclonal
Clone 319F6.07
Host Mouse
Isotype IgG2b
Shipping to Germany, USA/Canada
PDF datasheet View Datasheet
Manufacturer Dendritics SAS

Datasheet Extract

Immunogen
Swiss Prot Num:
P78556
Immunogen:
Human recombinant MIP3α in eukaryotic cells.
GeneID:
6364
Isotype control AM03110PU-N, SM12P
Application DDX0430P-50 / DDX0430P-100 Purified: Blocking migration, ELISA capture, IHC
Background Macrophage inflammatory protein (MIP)-3α/ CCL20 is a CC-type chemokine mapped to chromosome 2 in humans. Langerhans cells (LCs) represent a unique population of DCs colonizing epithelium. MIP-3α plays a central role in LC precursor recruitment into the epithelium during inflammation. (a) Among DC populations, MIP-3α is the most potent chemokine inducing the selective migration of in vitro-generated CD34+ hematopoietic progenitor cell-derived LC precursors and skin LCs in accordance with the restricted MIP-3α receptor (CC chemokine receptor 6) expression by these cells. (b) MIP-3α is mainly produced by epithelial cells, and the migration of LC precursors induced by the supernatant of activated skin keratinocytes is blocked with an antibody against MIP-3α. (c) In vivo, MIP-3α is selectively produced at sites of inflammation as illustrated in tonsils and lesional psoriatic skin where MIP-3α upregulation appears associated with an increase in LC turnover. (d) The secretion of MIP-3α is strongly upregulated by cells of epithelial origin after inflammatory stimuli (interleukin 1β plus TNFα) or T cell signals. (Dieu-Nosjean et al, J;Exp.med, 2000 192: 705-18).
Concentration 0.5 mg/ml
Product Citations
Originator or purchased from resellers:
  1. Dieu-Nosjean MC, Massacrier C, Homey B, Vanbervliet B, Pin JJ, Vicari A, et al. Macrophage inflammatory protein 3alpha is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med. 2000 Sep 4;192(5):705-18. PubMed PMID: 10974036. (Free PMC Article available, 10 images available)
  2. Homey B, Dieu-Nosjean MC, Wiesenborn A, Massacrier C, Pin JJ, Oldham E, et al. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol. 2000 Jun 15;164(12):6621-32. PubMed PMID: 10843722.
  3. Li Q, Estes JD, Schlievert PM, Duan L, Brosnahan AJ, Southern PJ, et al. Glycerol monolaurate prevents mucosal SIV transmission. Nature. 2009 Apr 23;458(7241):1034-8. doi: 10.1038/nature07831. Epub 2009 Mar 4. PubMed PMID: 19262509. (Free PMC Article available, 5 images available)
Storage -20°C. KEEP CONTENTS STERILE: no preservative.
Purified antibodies: avoid repeated freeze/thaw cycles.
Coupled antibodies: glycerol protects from freezing.
Format
Purification:
QMA Hyper D ion exchange chromatography
Buffer System:
Purified: 100 μg in 200μl /50 μg in 100 μl Tris-NaCl pH 8
State:
Purified
Specificity
Specificity:
Human MIP-3α.
Species cross-reactivity: Macaque.
Gene ID 6364

Accessory Products

Proteins and/or Positive Controls

Proteins for MIP3 alpha / CCL20 (16 products)

Catalog No. Species Pres. Purity   Source  

MIP3 alpha / CCL20 (transcript variant 1)

MIP3 alpha / CCL20 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
20 µg / €139.00
  OriGene Technologies, Inc.

MIP3 alpha / CCL20 (transcript variant 1)

MIP3 alpha / CCL20 Human > 98 %
Preparation: .
Purity Detail: >98%, as determined by Coomassie stained SDS-PAGE.
E. coli
10 µg / €105.00
  OriGene Technologies, Inc.

MIP3 alpha / CCL20 (27-96, His-tag)

MIP3 alpha / CCL20 Human Purified > 85 % E. coli
0.25 mg / €1,000.00
  OriGene Technologies GmbH

MIP3 alpha / CCL20 (27-96, His-tag)

MIP3 alpha / CCL20 Human Purified > 85 % E. coli
50 µg / €370.00
  OriGene Technologies GmbH

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human > 99 % E. coli
  OriGene Technologies GmbH

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human > 99 % E. coli
  OriGene Technologies GmbH

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Mouse > 99 % E. coli
  OriGene Technologies GmbH

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Mouse > 99 % E. coli
  OriGene Technologies GmbH

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human
  Abnova Taiwan Corp.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human
  Abnova Taiwan Corp.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human Purified
  Novus Biologicals Inc.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human Purified
  Novus Biologicals Inc.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human Purified
  Novus Biologicals Inc.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human Purified
  Novus Biologicals Inc.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human Purified
  Novus Biologicals Inc.

MIP3 alpha / CCL20

MIP3 alpha / CCL20 Human Purified
  Novus Biologicals Inc.

Positive controls for MIP3 alpha / CCL20 (2 products)

Catalog No. Species Pres. Purity   Source  

CCL20 overexpression lysate

CCL20 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.

Macrophage Inflammatory Protein 3 alpha Lysate

Western Blot: Macrophage Inflammatory Protein 3 alpha Lysate [NBL1-08850] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for CCL20
  Novus Biologicals Inc.
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