discontinued

MS109 Mitochondria Complex I (NADH Dehydrogenase) 8 kDa subunit antibody

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0.1 mg / €370.00

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Mouse anti Bovine, Human, Mouse, Rat Mitochondria Complex I (NADH Dehydrogenase) 17C8E4E11

Product Description for Mitochondria Complex I (NADH Dehydrogenase)

Mouse anti Bovine, Human, Mouse, Rat Mitochondria Complex I (NADH Dehydrogenase) 17C8E4E11.
Properties: 8 kDa subunit
Presentation: Purified
Product is tested for Western blot / Immunoblot.

Properties for Mitochondria Complex I (NADH Dehydrogenase)

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Purified
Reactivity Bov, Hu, Ms, Rt
Applications WB
Clonality Monoclonal
Clone 17C8E4E11
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer MitoSciences Inc.

Datasheet Extract

Immunogen
Immunogen:
Bovine Complex I.
Property 8 kDa subunit
Isotype control AM03095PU-N, SM10P (for use in human samples), SM20P (for use in rat samples)
Application Western Blot: 1.0 µg/ml.
Background Complex I, or NADH ubiquinone oxidoreductase, is a large protein complex of 950,000 Da molecular weight made up by 45 to 46 different subunits. A total of seven of the subunits of the complex are encoded by mitochondrial DNA, while the remainder subunits are nuclear encoded, which are translated in the cytosol and translocated into the organelle for assembly at the inner membrane. The enzyme complex catalyses electron entry from NADH via a flavin (FMN) and several non-heme iron centers. Complex I is sensitive to a wide range of inhibitors, many of which are pesticides or other common environmental toxins, such as rotenone. Complex I dysfunction is a common cause of genetic OXPHOS defects. Altered functioning of this complex is also thought to contribute to several neurological disorders including Parkinson’s disease and schizophrenia. Also, there is evidence of Complex I involvement in diabetes.
Concentration 1.0 mg/ml
General Readings 1. J Neurosci. 2006 May 10;26(19):5256-64.
"Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled."
2. Mol Cell Proteomics. 2005 Jan;4(1):84-96
"Rapid purification and mass spectrometric characterization of mitochondrial NADH dehydrogenase (Complex I) from rodent brain and a dopaminergic neuronal cell line."
Storage Store the antibody undiluted at 2-8°C.
DO NOT FREEZE!
Shelf life: one year from despatch.
Format
Purification:
Biochemical Fractionation.
Buffer System:
Hepes-Buffered Saline (HBS) with 0.02% Sodium Azide as a preservative.
State:
Liquid purified Ig fraction.
Purified
Species Reactivity
Species reactivity (tested):
Human, Bovine, Rat and Mouse.
Specificity
Specificity:
This antibody is reactive against an 8 kDa Complex I (NADH Dehydrogenase) subunit.
This antibody is useful in studying Complex I assembly.
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