NBP1-00927 MLH3 antibody

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Rabbit anti Human MLH3

Product Description for MLH3

Rabbit anti Human MLH3.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for MLH3

Product Category Primary Antibodies
Quantity 0.1 mg
Presentation Aff - Purified
Reactivity Hu
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Add. information Research Areas: DNA Repair
Application ELISA, Western Blot, Western blot analysis of MLH3 (R546) antibody in extracts from K562 cells. Detects a band at molecular weight: 164kDa, ELISA 1:40000-1:60000, Western Blot 1:500-1:1000,
Background DNA mismatch repair (MMR) is essential for maintaining the integrity of the genome during replication. This process is highly conserved across bacterial and eukaryotic systems, as many of the genes expressed in bacteria are closely related to the yeast and mammalian homologs. In bacteria two proteins, MutS and MutL, form homodimeric complexes that are responsible for recognizing and facilitating MMR. Human homologs of these proteins include MSH2 and MSH3 (MutS homolog 2 and 3), and the corresponding human homologs of MutL are MLH1, PMS1, PMS2 and MLH3. MSH2 and MSH3 form heterodimers that cooperatively mediate MMR. MLH3 preferentially dimerizes with MLH1 to repair DNA mismatches and restore the stability to the genome. Mutations in the genes encoding MSH2 and MLH1 induce microsatellite instablitiy of the DNA. These mutations are associated with the occurrence of hereditary nonpolyposis colorectal cancer (HNPCC) and are a common feature in the progression of many other cancers.
Concentration 1 mg/ml
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Immunogen affinity purified
Buffer System:
15mM Sodium Azide
Immunogen affinity purified
Aff - Purified
MLH3 (R546) detects endogenous levels of MLH3 protein.

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