discontinued

GTX18026 MLK3 (phospho Y277 + S281) pY277 / pS281 antibody

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50 µl / €370.00

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Rabbit anti Human, Mouse MLK3 (phospho Y277 + S281)

GTX18026

Product Description for MLK3 (phospho Y277 + S281)

Rabbit anti Human, Mouse MLK3 (phospho Y277 + S281).
Properties: pY277 / pS281
Presentation: Aff - Purified
Product is tested for Western blot / Immunoblot.

Properties for MLK3 (phospho Y277 + S281)

Product Category Primary Antibodies
Quantity 50 µl
Presentation Aff - Purified
Reactivity Hu, Ms
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

Immunogen
Immunogen:
Synthetic phosphopeptide derived from the region of human MLK3 that contains threonine 277 and serine 281. The sequence is conserved inmouse. (unfortunately, the amino acid sequence is considered to be commercially sensitive).
Property pY277 / pS281
Application WB
Background Members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dualleucine zipper kinase [DLK]) are serine/threonine protein kinases that are expressed in multiple cell types. MLK3 is activated by phosphorylation in response to stress stimuli (e.g., inflammatory responses, UV, chemical stress) that are coupled to the small GTPase, Cdc42/rac. MLK3 is amultifunctional kinase that plays an essential role in several signaling pathways, includingmitogen-activated protein kinase (i.e., activation of JNK and p38), IkappaB/NFkappaB, and p70 S6 kinase. Indeed MLK3 signaling occurs through multiple signaling domains in this protein kinase including (from N- to C-terminal) a glycine-rich domain, Src homology 3 (SH3) domain, a kinasedomain, a zipper domain, a Cdc42/rac interactive binding (CRIB) domain and a Pro/Ser/Thr-rich domain. Phosphorylation of MLK3 occurs on multiple residues including threonine 277 and serine 281 within the activation loop of the kinase domain.
Concentration 0.75 mg/ml
Storage Keep as concentrated solution. Store at 4
Format
Purification:
Immunogen affinity purified
Buffer System:
Preservative: 0.05% Sodium Azide. Constituents: 1mg/ml BSA. pH 7.3
Purity:
Immunogen affinity purified
State:
Aff - Purified
Specificity
Specificity:
Cross-reacts with Human.Expected to cross-react with Mouse (100% identity with immunogen) due to sequence homology. Not yet tested in other species.

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