AM05380PU-N MMP-9 (Active Protein) antibody

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0.2 mg / €370.00
Please visit the country specific website of Acris Antibodies or contact your local Distributor to buy this product.

Quick Overview

Mouse anti Human MMP-9 4A3

Product Description for MMP-9

Mouse anti Human MMP-9 4A3.
Properties: (Active Protein)
Presentation: Purified
Product is tested for Western blot / Immunoblot, Paraffin Sections.

Properties for MMP-9

Product Category Primary Antibodies
Target Category
Quantity 0.2 mg
Synonyms 92 kDa gelatinase, 92 kDa type IV collagenase, CLG4B, GELB, Gelatinase B, MMP9, Matrix metalloproteinase-9
Presentation Purified
Reactivity Hu
Applications P, WB
Clonality Monoclonal
Clone 4A3
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P14780
Immunogen:
Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the Nterminus of the human MMP9 protein and mouse myeloma Ag8563 cells. Sequence common in rabbit, dog and pig.
GeneID:
4318
Property Active Protein
Isotype control AM03095PU-N, SM10P (for use in human samples)
Application Western Blot: 1 - 2 µg/ml.
Immunohistochemistry on paraffin sections: 1 - 5 µg/ml.
Background The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92-kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP -1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.
Concentration Lot specific
General Readings
  1. Wang, L. et al. (2006). Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietinactivated endothelial cells promote neural progenitor cell migration. J. Neurosci. 26(22);5996 - 6003
  2. Somiari SB, Somiari RI, Heckman CM, Olsen CH, Jordan RM, Russell SJ, et al. Circulating MMP2 and MMP9 in breast cancer -- potential role in classification of patients into low risk, high risk, benign disease and breast cancer categories. Int J Cancer. 2006 Sep 15;119(6):1403-11. PubMed PMID: 16615109.
  3. Chen X, Su Y, Fingleton B, Acuff H, Matrisian LM, Zent R, et al. Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells. Int J Cancer. 2005 Aug 10;116(1):52-61. PubMed PMID: 15756690.
Storage The antibody can be shipped at ambient temperature. Store (in aliquots) at -20°C only.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Buffer System:
Phosphate buffered saline with 0.08% sodium azide
Purity:
Purified
State:
Liquid purified Ig
Purified
Specificity
Specificity:
This antibody reacts to Activated Matrix Metalloproteinase 9.
Species:
Human.
Gene ID 4318
FocusOn and Reviews
Reviews:

Accessory Products

Proteins and/or Positive Controls

Proteins for MMP-9 (7 products)

Catalog No. Species Pres. Purity   Source  

MMP-9

MMP-9 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MMP-9

MMP-9 Human > 95 % pure by SDS-PAGE: This preparation is free from gelatinase B dimers and from complexes of gelatinase B with TIMP-1 or lipocalin. Blood
  Acris Antibodies GmbH

MMP-9

MMP-9 Human
  Abnova Taiwan Corp.

MMP-9

MMP-9 Human Purified
  Abnova Taiwan Corp.

MMP-9

MMP-9 Human Purified
  Abnova Taiwan Corp.

MMP-9

MMP-9 Human
  Abnova Taiwan Corp.

MMP-9

MMP-9 Human
  Abnova Taiwan Corp.

Positive controls for MMP-9 (2 products)

Catalog No. Species Pres. Purity   Source  

MMP9 Lysate

Western Blot: MMP9 Lysate [NBL1-13162] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for MMP9
  Novus Biologicals Inc.

MMP9 overexpression lysate

MMP9 overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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